中西医结合治疗外阴上皮内非瘤样病变临床观察

发布时间：2018-07-17 05:56

【摘要】：目的观察中西医结合治疗外阴上皮内非瘤样病变的疗效。方法将100例门诊病理确诊为外阴上皮内非瘤样病变女性患者,分为中西医结合组(治疗组)和西药组(对照组),每组50例,治疗组口服滋补肝肾、养血祛风中药,同时每晚睡前将该方药渣煎水500mL,坐浴5～10min;每天用金甘油(本院自制皮肤外用药,主要成分:金霉素、甘油等)涂抹外阴病变处2次。对照组每天用温水坐浴5～10min,金甘油涂抹外阴病变处2次。均以治疗2个月为1个疗程,治疗1个疗程并随访2个月后进行疗效评定,观察治疗前后局部皮肤病损程度、阴部痒痛程度及局部病变组织中雌、孕激素受体水平。结果治疗组临床总有效率为94%(47/50),对照组为66%(33/50)。两组治疗结束2月后阴部局部皮肤病损程度、阴部痒痛程度症状积分比较差异均有统计学意义(P0.01),治疗组优于对照组。而两组局部病变组织中雌、孕激素受体阳性率比较差异无统计学意义。结论中西医结合治疗方法能有效治疗外阴上皮内非瘤样病变,并明显改善相关临床症状。
[Abstract]:Objective to observe the therapeutic effect of integrated traditional Chinese and western medicine on non-tumor-like lesions of vulva. Methods 100 cases of female patients with vulvar intraepithelial nonneoplastic lesions confirmed by pathology in outpatient department were divided into two groups: the treatment group (treatment group) and the western medicine group (control group). 50 cases in each group were treated with oral nourishing liver and kidney, nourishing blood and expelling wind. At the same time, the prescription was fried with 500mL of dregs before going to bed every night, sitting bath for 510min, and the vulvar lesion was smeared twice a day with gold glycerin (self-made skin medicine, main ingredients: chlortetracycline, glycerol, etc.). In the control group, warm water was used for 5 minutes and gold glycerol was applied to vulva lesion twice a day. All patients were treated for 2 months as a course of treatment and followed up for 2 months to evaluate the curative effect. The degree of local skin lesions, the degree of pudendal itch pain and the levels of estrogen and progesterone receptors in local pathological tissues were observed before and after treatment. Results the total effective rate was 94% (47 / 50) in the treatment group and 66% (33 / 50) in the control group. Two months after the treatment, there were significant differences in the degree of local skin lesions and the degree of pruritic pain between the two groups (P0.01), and the treatment group was superior to the control group. There was no significant difference in the positive rate of estrogen and progesterone receptor between the two groups. Conclusion combined Chinese and western medicine can effectively treat non-tumor-like lesions of vulva and improve the clinical symptoms.
【作者单位】：华中科技大学同济医学院附属中西医结合医院;
【基金】：武汉市卫生局资助课题〔武卫(2004)241号〕
【分类号】：R711.72

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