中西医结合治疗小儿原发性肾病综合征的系统评价
发布时间：2018-07-25 18:09
【摘要】：目的 通过翻阅文献,用循证医学的方法,评价中西医结合治疗小儿原发性肾病综合征的疗效,为中西医结合治疗小儿原发性肾病综合征提供科学依据。 方法 选用国内外多个权威数据库为资料源,对国内外近十年间(2001-2011)已发表的临床研究文献进行电子及手工检索,按照国际Cochrane协作网的系统评价方法,计算机检索维普期刊全文数据库(VIP)、中国知网全文数据库(CNKI)、万方数据库、中国生物医学文献数据库(CBM); Pubmed(1979-2011)、医知网等数据库,及学术会议资料和学位论文。手工检索2011年下半年的10余种中文核心期刊。对所纳入的研究进行方法学质量评价,并选取质量良好的随机对照试验运用Rev.Man5.0.软件进行Meta分析。 结果 共检索到18个符合纳入标准的临床试验,共计1081例病人。Meta-分析显示：在相同的基础治疗上中西医结合组对小儿PNS的治疗与同期平行随机对照的西药组相比较,显示了更好的临床疗效,更好地改善症状体征,降低24h尿蛋白定量水平、血胆固醇、甘油三酯、尿素氮、血浆比粘度、复发率,明显减少激素的副作用,并增加血浆白蛋白,对血肌酐、血沉、全血粘度指标无统计学意义。但纳入的文献方法学质量评价较低。 结论 本研究提示中西医结合组治疗小儿PNS与单独使用西药治疗结果相比,可提高临床疗效,减少不良反应。但由于纳入的临床试验方法学质量相对偏低,样本量偏小,存在多种局限性,故对这些结果的解释应持谨慎态度。
[Abstract]:Objective to evaluate the efficacy of integrated traditional Chinese and western medicine in the treatment of pediatric primary nephrotic syndrome by reviewing the literature and using the method of evidence-based medicine to provide scientific basis for the treatment of pediatric primary nephrotic syndrome with the combination of traditional Chinese and western medicine. Methods A number of authoritative databases at home and abroad were selected as data sources to carry out electronic and manual retrieval of clinical research literature published in recent ten years (2001-2011), and the systematic evaluation method of international Cochrane cooperation network was used. To search the full text database of Weip journal (VIP), (CNKI), Wanfang database, (CBM); Pubmed (1979-2011, and other databases, as well as academic conference materials and degree papers. Manual retrieval of more than 10 Chinese core journals in the second half of 2011. To evaluate the methodological quality of the included studies, and select a good quality randomized controlled trial with Rev.Man5.0. Software Meta analysis. Results A total of 18 clinical trials that met the inclusion criteria were retrieved. A total of 1081 patients. Meta- analysis showed that the treatment of pediatric PNS in the integrated Chinese and western medicine group was compared with that in the parallel randomized control group in the same basic treatment. It showed better clinical effect, improved symptoms and signs, reduced 24-hour urinary protein levels, serum cholesterol, triglyceride, urea nitrogen, plasma specific viscosity, recurrence rate, significantly reduced side effects of hormones, and increased plasma albumin. There was no significant difference in serum creatinine, erythrocyte sedimentation rate and whole blood viscosity. However, the quality evaluation of literature methodology included is relatively low. Conclusion this study suggests that the combination of traditional Chinese and western medicine in the treatment of children with PNS can improve the clinical efficacy and reduce adverse reactions compared with western medicine alone. However, the quality of clinical trial methodology is relatively low, sample size is small, and there are many limitations, so the interpretation of these results should be cautious.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R726.9
本文编号：2144617
[Abstract]:Objective to evaluate the efficacy of integrated traditional Chinese and western medicine in the treatment of pediatric primary nephrotic syndrome by reviewing the literature and using the method of evidence-based medicine to provide scientific basis for the treatment of pediatric primary nephrotic syndrome with the combination of traditional Chinese and western medicine. Methods A number of authoritative databases at home and abroad were selected as data sources to carry out electronic and manual retrieval of clinical research literature published in recent ten years (2001-2011), and the systematic evaluation method of international Cochrane cooperation network was used. To search the full text database of Weip journal (VIP), (CNKI), Wanfang database, (CBM); Pubmed (1979-2011, and other databases, as well as academic conference materials and degree papers. Manual retrieval of more than 10 Chinese core journals in the second half of 2011. To evaluate the methodological quality of the included studies, and select a good quality randomized controlled trial with Rev.Man5.0. Software Meta analysis. Results A total of 18 clinical trials that met the inclusion criteria were retrieved. A total of 1081 patients. Meta- analysis showed that the treatment of pediatric PNS in the integrated Chinese and western medicine group was compared with that in the parallel randomized control group in the same basic treatment. It showed better clinical effect, improved symptoms and signs, reduced 24-hour urinary protein levels, serum cholesterol, triglyceride, urea nitrogen, plasma specific viscosity, recurrence rate, significantly reduced side effects of hormones, and increased plasma albumin. There was no significant difference in serum creatinine, erythrocyte sedimentation rate and whole blood viscosity. However, the quality evaluation of literature methodology included is relatively low. Conclusion this study suggests that the combination of traditional Chinese and western medicine in the treatment of children with PNS can improve the clinical efficacy and reduce adverse reactions compared with western medicine alone. However, the quality of clinical trial methodology is relatively low, sample size is small, and there are many limitations, so the interpretation of these results should be cautious.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R726.9
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