中西医结合治疗幽门螺旋杆菌阳性消化性溃疡44例

发布时间：2018-07-27 16:50

【摘要】：目的:观察清幽I号方联合四联疗法对消化性溃疡(PU)幽门螺杆菌(Hp)的根除率及对溃疡复发的影响。方法:88例PU患者随机按数字法分为对照组和观察组各44例。对照组服用奥美拉唑,20 mg/次,2次/d;枸橼酸铋钾片,2粒/次,2次/d;阿莫西林胶囊,1 g/次,2次/d;克拉霉素,500 mg/次,2次/d。疗程为14 d。14 d后再采用法莫替丁,20 mg/次,1次/d,再治疗14 d。观察组在对照组治疗的基础上加用清幽I号方,1剂/d,常规水煎分2次服用,共28 d。记录治疗后Hp清除情况;采用组织学再生黏膜成熟度评价溃疡愈合质量;进行1年随访观察复发情况。结果:观察组总体疗效有效率为97.73%,对照组为81.82%,观察组优于对照组(P0.05);观察组Hp清除率为90.9%,对照组为75%,观察组Hp清除率高于对照组(P0.05);观察组再生黏膜组织学成熟度评价优于对照组(P0.05);对照组13例复发,复发率45.16%,观察组8例复发,复发率20%,观察组复发率低于对照组(P0.05);观察组平均复发时间(10.1±1.93)个月长于对照组的(8.7±1.84)个月(P0.05)。结论:在常规四联疗法的基础上加服清幽I号方能提高Hp清除率,提高溃疡愈合质量,减少/延缓PU复发,提高临床疗效。
[Abstract]:Objective: to observe the eradication rate of Helicobacter pylori (Hp) in peptic ulcer (PU) and the effect of Qingyou I recipe combined with tetralogy therapy on ulcer recurrence. Methods 88 patients with pu were randomly divided into control group (n = 44) and observation group (n = 44). The control group was treated with omeprazole for 20 mg/ d; bismuth potassium citrate tablet for 2 / 2 / d; amoxicillin capsule for 1 g / 2 / 2 / d; clarithromycin for 500 mg/ twice / d. The course of treatment was 14d.14 days later, then the patients were treated with famotidine for 20 mg/ s / d, and then treated for 14 days. On the basis of the treatment in the control group, the observation group was given 1 dose / d of Qingyou I recipe, and the routine decoction was taken twice for 28 days. HP clearance after treatment was recorded, ulcer healing quality was evaluated by histological regeneration mucosal maturity, and recurrence was observed after 1 year follow-up. Results: the total effective rate of observation group was 97.73 and that of control group was 81.82, which was superior to that of control group (P0.05), the HP clearance rate of observation group was 90.9, and that of control group was 75.The HP clearance rate of observation group was higher than that of control group (P0.05); the histological maturity of regenerated mucosa in observation group was higher than that in control group (P0.05). The value was better than that in the control group (P0.05), and the recurrence rate in the control group was 13. The recurrence rate in the observation group was lower than that in the control group (P0.05), and the mean recurrence time in the observation group was (10.1 卤1.93) months longer than that in the control group (8.7 卤1.84) months (P0.05). Conclusion: taking Qingyou I prescription on the basis of routine quadruple therapy can improve HP clearance, improve ulcer healing quality, reduce / delay pu recurrence, and improve clinical efficacy.
【作者单位】：固原市原州区人民医院;北京天坛医院;
【基金】：宁夏省卫生厅医学基金项目(2012LWS1102)
【分类号】：R573.1

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