糖皮质激素辅以针灸治疗对重症肌无力患者免疫球蛋白及补体的影响研究

发布时间：2018-08-06 15:28

【摘要】：目的探讨糖皮质激素(GC)辅以针灸治疗对重症肌无力(MG)患者的免疫调节疗效及机制。方法将68例患者采用抽签法随机分为2组,每组34例。治疗组GC辅以针灸治疗;对照组单用GC治疗,疗程2个月,观察两组患者治疗前后症状改善情况及外周血免疫球蛋白及补体的水平。结果经治疗2个月后,治疗组临床总有效率为85%(29/34);对照组临床总有效率为82%(28/34),两组间差异无统计学意义(P0.05);治疗前两组MG患者血清IgG1、IgG3均高于健康组,C3低于健康组,差异均有统计学意义(P0.05),IgM、IgA和C4、IgG2、IgG4与健康组比较差异均无统计学意义(P0.05);经2个月治疗,治疗组与对照组IgG1、C3较治疗前差异有统计学意义(P0.01);治疗组与对照组比较,IgG1差异有统计学意义(P0.05),IgG3和C3差异无统计学意义(P0.05)。结论 GC可能通过对体液免疫等功能的影响而发挥治疗作用,针灸治疗可能对MG患者的免疫功能有调节作用。
[Abstract]:Objective to investigate the immunomodulatory effect and mechanism of glucocorticoid (GC) combined with acupuncture in patients with myasthenia gravis (MG). Methods 68 patients were randomly divided into 2 groups, 34 cases in each group. GC was treated with acupuncture and moxibustion in the treatment group and the control group was treated with GC for 2 months. The improvement of symptoms and the level of immunoglobulin and complement in peripheral blood were observed before and after treatment. Results after 2 months of treatment, the total effective rate in the treatment group was 85% (29 / 34), the total effective rate in the control group was 82% (28 / 34), there was no significant difference between the two groups (P0.05). The differences were statistically significant (P0.05). There was no significant difference in IgA and C _ 4 IgG _ 2G _ 4 between the two groups (P0.05), and after 2 months of treatment, there was no significant difference between the two groups (P0.05). Compared with the control group, the treatment group and the control group had significant difference in IgG1C 3 (P0.01), and the treatment group and the control group had significant difference in IgG1 (P0.05). There was no significant difference in IgG3 and C3 between the treatment group and the control group (P0.05). Conclusion GC may play a therapeutic role by affecting humoral immunity and acupuncture therapy may regulate the immune function of MG patients.
【作者单位】：兰州大学第二医院神经内科;兰州大学第二医院中医科;
【分类号】：R246.6;R746.1

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