中西医结合治疗肺源性心脏病急性发作期疗效的系统评价
发布时间：2018-08-29 18:25
【摘要】：目的： 本研究收集已有的中西医结合治疗慢性肺源性心脏病急性发作期的随机对照试验并对其进行系统评价,探讨其临床疗效和安全性,对研究质量的总体水平作出评估,以对将来的临床决策提供循证医学参考依据。 方法： 计算机检索1991年至2011年间中国生物医学文献数据库、维普中文科技期刊数据库、中国知网数据库、万方学位论文数据库,手工检索上述数据库中无法下载或者未收录入计算机数据库的相关期刊、会议论文及各大专院校校报等。再对符合纳入标准的研究文献进行资料提取和质量评价,并用Reman5.0软件对主要结局指标临床有效率及次要结局指标血浆比黏度、红细胞压积、氧分压、二氧化碳分压等相关数据进行Meta分析。 结果： 依据纳入与排除标准,总共纳入研究文献55篇,共计4863名慢性肺源性心脏病急性发作期患者。分析结果显示：中西医结合治疗比用单纯西医治疗有效率更高；中西医结合治疗比用单纯西医治疗能更有效的降低血浆比黏度、红细胞压积、二氧化碳分压,升高氧分压。 结论： 中西医结合用药对治疗慢性肺源性心脏病急性发作期的有效率高于单纯使用西药；中西医结合对降低血浆比黏度、红细胞压积、二氧化碳分压,升高氧分压的程度优于西药；虽然不存在统计学差异,但由于存在异质性较大的原因,仍需更多的临床试验研究验证。由于本研究纳入的文献质量较低,各个试验存在的偏倚较大,而Meta分析作为一种定量性分析,属于描述性的二次分析,其结论受原始文献研究数据的影响较大,在临床实践和科研中应该正确认识和合理利用系统评价与Meta分析,不应当盲目过分依赖上述的分析结果。
[Abstract]:Objective: to investigate the clinical efficacy and safety of a randomized controlled trial of integrated traditional Chinese and western medicine in the treatment of acute attack of chronic pulmonary heart disease. The overall level of research quality was evaluated to provide evidence-based medical reference for future clinical decision-making. Methods: Chinese biomedical literature database, Weipu Chinese science and technology journal database, Chinese knowledge network database and Wanfang degree thesis database were searched by computer from 1991 to 2011. Manually search the related journals, conference papers and college newspapers which cannot be downloaded or not included in the computer database. Then the data were extracted and the quality was evaluated according to the inclusion criteria. The clinical efficacy and secondary outcome indexes of the main outcome indicators, namely plasma viscosity, hematocrit, partial pressure of oxygen, were evaluated by Reman5.0 software. Carbon dioxide partial pressure and other related data were analyzed by Meta. Results: according to the inclusion and exclusion criteria, a total of 55 articles were included in the study, with a total of 4863 patients with acute attack of chronic pulmonary heart disease. The results showed that the effective rate of integrated traditional Chinese and western medicine was higher than that of western medicine alone, and the combination of traditional Chinese and western medicine could reduce plasma viscosity, hematocrit, partial pressure of carbon dioxide and increase partial pressure of oxygen more effectively than that of western medicine alone. Conclusion: the effective rate of integrated traditional Chinese and western medicine in the treatment of acute attack of chronic pulmonary heart disease is higher than that of western medicine alone, and it can reduce plasma viscosity, hematocrit and partial pressure of carbon dioxide. The degree of increasing oxygen partial pressure is better than that of western medicine, although there is no statistical difference, but due to the existence of greater heterogeneity, there is still need for more clinical trials to verify. Because of the low quality of the literature included in this study and the bias of each experiment, the Meta analysis, as a quantitative analysis, belongs to the descriptive secondary analysis, and its conclusion is greatly influenced by the original literature research data. In clinical practice and scientific research, the system evaluation and Meta analysis should be correctly recognized and reasonably used, and the above analysis results should not be blindly relied on.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R541.5
本文编号：2212034
[Abstract]:Objective: to investigate the clinical efficacy and safety of a randomized controlled trial of integrated traditional Chinese and western medicine in the treatment of acute attack of chronic pulmonary heart disease. The overall level of research quality was evaluated to provide evidence-based medical reference for future clinical decision-making. Methods: Chinese biomedical literature database, Weipu Chinese science and technology journal database, Chinese knowledge network database and Wanfang degree thesis database were searched by computer from 1991 to 2011. Manually search the related journals, conference papers and college newspapers which cannot be downloaded or not included in the computer database. Then the data were extracted and the quality was evaluated according to the inclusion criteria. The clinical efficacy and secondary outcome indexes of the main outcome indicators, namely plasma viscosity, hematocrit, partial pressure of oxygen, were evaluated by Reman5.0 software. Carbon dioxide partial pressure and other related data were analyzed by Meta. Results: according to the inclusion and exclusion criteria, a total of 55 articles were included in the study, with a total of 4863 patients with acute attack of chronic pulmonary heart disease. The results showed that the effective rate of integrated traditional Chinese and western medicine was higher than that of western medicine alone, and the combination of traditional Chinese and western medicine could reduce plasma viscosity, hematocrit, partial pressure of carbon dioxide and increase partial pressure of oxygen more effectively than that of western medicine alone. Conclusion: the effective rate of integrated traditional Chinese and western medicine in the treatment of acute attack of chronic pulmonary heart disease is higher than that of western medicine alone, and it can reduce plasma viscosity, hematocrit and partial pressure of carbon dioxide. The degree of increasing oxygen partial pressure is better than that of western medicine, although there is no statistical difference, but due to the existence of greater heterogeneity, there is still need for more clinical trials to verify. Because of the low quality of the literature included in this study and the bias of each experiment, the Meta analysis, as a quantitative analysis, belongs to the descriptive secondary analysis, and its conclusion is greatly influenced by the original literature research data. In clinical practice and scientific research, the system evaluation and Meta analysis should be correctly recognized and reasonably used, and the above analysis results should not be blindly relied on.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R541.5
【参考文献】
相关期刊论文 前10条
1 李可建;;补阳还五汤化裁治疗慢性肺心病急性发作期的系统评价[J];中医药临床杂志;2007年02期
2 张海泉;;加味小青龙汤对慢性肺心病急性发作期的改善作用[J];中医药临床杂志;2012年04期
3 蔡建郁;;利水汤治疗肺心病水肿30例临床观察[J];中医药导报;2011年03期
4 陈保霞;王长禄;;中西医结合治疗肺原性心脏病30例[J];河南中医;2010年09期
5 薛国新;;温补汤治疗慢性肺原性心脏病50例[J];河南中医;2011年05期
6 任花;;刘文峰教授自拟泻肺强心汤治疗肺心病经验拾萃[J];环球中医药;2010年05期
7 许文忠;张立新;梅建强;;中西医结合综合疗法对肺心病急性发作期血常规和血流变的影响[J];河北中医药学报;2011年02期
8 徐勇;周铁中;;血府逐瘀汤联合肝素雾化吸入治疗肺原性心脏病高黏血症30例[J];河南中医;2012年10期
9 张胜;;葶苈泻肺汤应用于肺原性心脏病急性加重期28例疗效观察[J];河南中医;2012年06期
10 王颖;;扶正固本法治疗肺心病缓解期临床观察[J];辽宁中医药大学学报;2012年03期
，本文编号：2212034
本文链接：https://www.wllwen.com/yixuelunwen/zhxiyjh/2212034.html
