穴位埋线治疗慢性阻塞性肺疾病的临床研究及其对患者血清TNF-α、IL-8的干预作用

发布时间：2018-11-10 14:00

【摘要】：目的:观察穴位埋线治疗慢性阻塞性肺疾病(COPD)的疗效及其对患者血清肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)的干预作用。方法:将COPD稳定期患者随机分为埋线组(40例)和对照组(41例),埋线组予以穴位埋线治疗联合西医常规治疗,对照组予以西医常规治疗。比较两组治疗前后6个月内COPD急性加重(AECOPD)次数、重度AECOPD次数、肺功能、血清中TNF-α、IL-8水平。结果:埋线组患者治疗后6个月内AECOPD次数、重度AECO-PD次数较治疗前明显减少(P0.01),血清中TNF-α、IL-8水平较治疗前明显降低(P0.01),且与对照组治疗后相比差异均有统计学意义(P0.05)。但两组治疗前后肺功能均未见差异(P0.05)。结论:穴位埋线治疗COPD患者可以减少AECOPD次数,特别是重度AECOPD次数,改善患者生活质量,其治疗机制可能与下调患者血清中TNF-α和IL-8水平有关。
[Abstract]:Objective: to observe the effect of catgut embedding at acupoints on (COPD) and its intervention on serum tumor necrosis factor- 伪 (TNF- 伪) and interleukin-8 (IL-8) in patients with chronic obstructive pulmonary disease (COPD). Methods: COPD patients were randomly divided into catgut embedding group (n = 40) and control group (n = 41). The number of acute exacerbations of (AECOPD), the number of severe AECOPD, pulmonary function, serum TNF- 伪 and IL-8 levels were compared between the two groups within 6 months before and after treatment. Results: the number of AECOPD, severe AECO-PD and serum TNF- 伪 and IL-8 levels in the patients with catgut embedding group were significantly lower than those before treatment (P0.01), and the levels of TNF- 伪 and IL-8 in serum were significantly lower than those before treatment (P0.01). And compared with the control group after treatment, the difference was statistically significant (P0.05). But there was no difference in pulmonary function between the two groups before and after treatment (P0.05). Conclusion: acupoint catgut implantation can reduce the number of AECOPD, especially severe AECOPD, and improve the quality of life in patients with COPD. The therapeutic mechanism may be related to the down-regulation of serum TNF- 伪 and IL-8 levels.
【作者单位】：上海中医药大学附属岳阳中西医结合医院;郴州市中医院内二科;上海中医药大学附属岳阳中西医结合医院针灸科;
【分类号】：R245.91

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