中西医结合治疗原发性肝癌射频消融术后合并急性消化道出血的效果及对VEGF蛋白表达的影响
发布时间：2018-11-11 21:37
【摘要】：目的观察原发性肝癌(简称肝癌)射频消融术后合并急性消化道出血的中西医结合治疗效果及对血管内皮生长因子(VEGF)蛋白表达的影响。方法将43例符合要求的肝癌合并急性消化道出血患者随机分为观察组22例和对照组21例。观察组以加减圣愈汤为主配合注射用血凝酶+埃索美拉唑钠治疗,对照组单纯用注射用血凝酶+埃索美拉唑钠治疗。比较两组止血疗效、大便潜血转阴时间、平均住院时间、不良反应率、VEGF蛋白表达水平。结果经过观察对比,观察组止血有效率95.45%明显高于对照组的76.19%(P0.05);观察组总不良反应率明显低于对照组(P0.05);观察组潜血转阴时间明显低于对照组(P0.05);观察组平均住院时间明显低于对照组(P0.05)。结论以中药圣愈汤加减配合西药治疗肝癌射频消融术后合并消化道出血在提高止血疗效、缩减大便潜血时间、降低药物不良反应及缩短平均住院时间方面优于单纯西药治疗,同时可以提高机体免疫力,降低VEGF蛋白表达。
[Abstract]:Objective to observe the effect of integrated Chinese and western medicine on the expression of vascular endothelial growth factor (VEGF) protein after radiofrequency ablation of hepatocellular carcinoma (HCC) with acute gastrointestinal hemorrhage. Methods 43 patients with HCC complicated with acute gastrointestinal hemorrhage were randomly divided into two groups: the observation group (n = 22) and the control group (n = 21). The observation group was treated mainly with Jiajianshengyu decoction combined with esomeprazole sodium for injection, while the control group was only treated with esomeprazole sodium for injection. The hemostatic effect, the time of occult blood conversion, the average hospitalization time, the adverse reaction rate and the expression of VEGF protein were compared between the two groups. Results the effective rate of hemostasis was 95.45% in the observation group and 76.19% in the control group (P0.05), and the total adverse reaction rate in the observation group was significantly lower than that in the control group (P0.05). The time of occult blood turning negative in the observation group was significantly lower than that in the control group (P0.05), and the average hospitalization time in the observation group was significantly lower than that in the control group (P0.05). Conclusion the combination of Shengyu decoction and western medicine in the treatment of hepatoma combined with gastrointestinal bleeding after radiofrequency ablation is superior to that of western medicine alone in improving the hemostatic effect, reducing the time of occult blood in stool, reducing the adverse drug reaction and shortening the average hospital stay. At the same time, it can improve immunity and reduce the expression of VEGF protein.
【作者单位】： 广州中医药大学第一附属医院肿瘤中心肿瘤一区;
【基金】：广东省自筹经费类科技计划项目(编号:411297863058)
【分类号】：R735.7
本文编号：2326210
[Abstract]:Objective to observe the effect of integrated Chinese and western medicine on the expression of vascular endothelial growth factor (VEGF) protein after radiofrequency ablation of hepatocellular carcinoma (HCC) with acute gastrointestinal hemorrhage. Methods 43 patients with HCC complicated with acute gastrointestinal hemorrhage were randomly divided into two groups: the observation group (n = 22) and the control group (n = 21). The observation group was treated mainly with Jiajianshengyu decoction combined with esomeprazole sodium for injection, while the control group was only treated with esomeprazole sodium for injection. The hemostatic effect, the time of occult blood conversion, the average hospitalization time, the adverse reaction rate and the expression of VEGF protein were compared between the two groups. Results the effective rate of hemostasis was 95.45% in the observation group and 76.19% in the control group (P0.05), and the total adverse reaction rate in the observation group was significantly lower than that in the control group (P0.05). The time of occult blood turning negative in the observation group was significantly lower than that in the control group (P0.05), and the average hospitalization time in the observation group was significantly lower than that in the control group (P0.05). Conclusion the combination of Shengyu decoction and western medicine in the treatment of hepatoma combined with gastrointestinal bleeding after radiofrequency ablation is superior to that of western medicine alone in improving the hemostatic effect, reducing the time of occult blood in stool, reducing the adverse drug reaction and shortening the average hospital stay. At the same time, it can improve immunity and reduce the expression of VEGF protein.
【作者单位】： 广州中医药大学第一附属医院肿瘤中心肿瘤一区;
【基金】：广东省自筹经费类科技计划项目(编号:411297863058)
【分类号】：R735.7
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