中西医结合治疗对中重度痤疮患者外周血炎症因子IL-17、IL-18、IFN-γ的影响
发布时间：2018-11-18 07:18
【摘要】：目的:痤疮是临床常见皮肤病,与中医的“肺风粉刺”相类似,发病机制较为复杂,现代医学认为痤疮丙酸杆菌及炎症反应在整个痤疮发病过程中尤为重要,痤疮丙酸杆菌可刺激机体产生多种炎症因子,有研究报道IL-17、IL-18和IFN-γ与炎症反应相关,但与痤疮具体关系尚不明确。痤疮影响因素多,治疗困难,临床上多采用内外同治、中西医结合联合抗炎的方法治疗,其中,口服丹参酮胶囊、米诺环素联合外用夫西地酸乳膏的治疗方案取得较满意疗效。因此,为了研究IL-17、IL-18和IFN-γ与痤疮的相关性,我们选择口服丹参酮胶囊、米诺环素联合外用夫西地酸乳膏的治疗方案治疗中重度痤疮患者,检测患者治疗前后外周血中IL-17、IL-18和IFN-γ的水平,并且与健康对照组进行比较,探讨这些炎症因子水平与中重度痤疮之间的关系。方法:1.选择符合入选标准的中重度痤疮患者30例作为试验组,选择20例健康志愿者作为对照组。2.试验组给予丹参酮胶囊(规格:250mg×24粒,河北兴隆希力药业)1.0g,每日3次口服;盐酸米诺环素胶囊(规格:50mg×20粒,惠氏制药有限公司)50mg,每日2次口服;夫西地酸乳膏(规格:5g:0.1g,香港澳美制药厂),适量,每天2次涂于患处,连续治疗8周。对照组不做任何处理。3.分别抽取对照组,试验组治疗前、试验组治疗后的清晨空腹静脉血3ml,离心取上清,-20℃保存备用。4.用IL-17、IL-18和IFN-γ酶联免疫吸附测定(ELISA)试剂盒(伊莱瑞特生物科技有限公司)分别检测IL-17、IL-18和IFN-γ的血清水平。结果:1.口服丹参酮胶囊联合盐酸米诺环素胶囊配合外用夫西地酸乳膏治疗中重度痤疮,有效率达90%,不良反应少。2.血清中IL-17的水平:对照组为(9.78±1.04)pg/ml,试验组治疗前为(15.27±3.79)pg/ml,试验组治疗后为(10.88±1.42)pg/ml。试验组治疗后较治疗前水平降低(P0.05),试验组治疗前后的水平均高于对照组(P0.05)。3.血清中IL-18的水平:对照组为(14.65±2.17)pg/ml,试验组治疗前为(21.87±5.93)pg/ml,试验组治疗后为(15.91±4.81)pg/ml。试验组治疗后较治疗前水平降低(P0.05),试验组治疗后的水平与对照组无统计学差异(P0.05)。4.血清中IFN-γ的水平:对照组为(889.79±197.82)pg/ml,试验组治疗前为(504.91±186.70)pg/ml,试验组治疗后为(767.74±200.45)pg/ml。试验组治疗后的水平较治疗前升高(P0.05),但是仍低于对照组(P0.05)。结论:1.口服丹参酮胶囊联合盐酸米诺环素胶囊配合外用夫西地酸乳膏治疗中重度痤疮,疗效好,不良反应少。2.中重度痤疮患者外周血IL-17和IL-18的水平高于健康人,IFN-γ的水平低于健康人。3.经中西医结合联合抗炎治疗8周后,中重度痤疮患者皮疹好转,炎症减轻,外周血IL-17和IL-18的水平降低,IFN-γ的水平升高。
[Abstract]:Objective: acne is a common clinical skin disease, similar to the traditional Chinese medicine "lung wind acne", the pathogenesis is more complex, modern medicine believes that acne Propionibacterium and inflammatory reaction in the whole process of acne is particularly important. Propionibacterium acnes can stimulate the production of many inflammatory factors. It has been reported that IL-17,IL-18 and IFN- 纬 are related to inflammatory reaction, but the specific relationship with acne is not clear. Acne is affected by many factors and difficult to treat. It is often treated with both internal and external treatment and combination of traditional Chinese and western medicine with anti-inflammatory methods. Among them, oral tanshinone capsule and minocycline combined with external Fusidic acid cream have achieved satisfactory curative effect. Therefore, in order to study the correlation between IL-17,IL-18 and IFN- 纬 and acne, we chose oral tanshinone capsule, minocycline combined with topical Fusidic acid cream to treat moderate and severe acne patients. The levels of IL-17,IL-18 and IFN- 纬 in peripheral blood of patients before and after treatment were measured and compared with those of healthy controls to explore the relationship between the levels of these inflammatory factors and moderate and severe acne. Methods: 1. Thirty moderate and severe acne patients were selected as trial group and 20 healthy volunteers as control group. Tanshinone capsules (specification: 250mg 脳 24, Hebei Xinglong Xili Pharmaceutical Industry) 1.0 g, Minocycline Hydrochloride capsules (50mg 脳 20, Wyeth Pharmaceutical Co., Ltd.) 50mg twice a day; Fossidy yoghurt cream (5 g: 0.1 g, Hong Kong, Australia and American Pharmaceutical Factory), 2 times a day, applied to affected area, continuous treatment for 8 weeks. The control group did not do any treatment. 3. The control group, the experimental group before treatment, the test group after treatment of fasting venous blood 3 ml in the morning, centrifuged supernatant, -20 鈩，
本文编号：2339289
[Abstract]:Objective: acne is a common clinical skin disease, similar to the traditional Chinese medicine "lung wind acne", the pathogenesis is more complex, modern medicine believes that acne Propionibacterium and inflammatory reaction in the whole process of acne is particularly important. Propionibacterium acnes can stimulate the production of many inflammatory factors. It has been reported that IL-17,IL-18 and IFN- 纬 are related to inflammatory reaction, but the specific relationship with acne is not clear. Acne is affected by many factors and difficult to treat. It is often treated with both internal and external treatment and combination of traditional Chinese and western medicine with anti-inflammatory methods. Among them, oral tanshinone capsule and minocycline combined with external Fusidic acid cream have achieved satisfactory curative effect. Therefore, in order to study the correlation between IL-17,IL-18 and IFN- 纬 and acne, we chose oral tanshinone capsule, minocycline combined with topical Fusidic acid cream to treat moderate and severe acne patients. The levels of IL-17,IL-18 and IFN- 纬 in peripheral blood of patients before and after treatment were measured and compared with those of healthy controls to explore the relationship between the levels of these inflammatory factors and moderate and severe acne. Methods: 1. Thirty moderate and severe acne patients were selected as trial group and 20 healthy volunteers as control group. Tanshinone capsules (specification: 250mg 脳 24, Hebei Xinglong Xili Pharmaceutical Industry) 1.0 g, Minocycline Hydrochloride capsules (50mg 脳 20, Wyeth Pharmaceutical Co., Ltd.) 50mg twice a day; Fossidy yoghurt cream (5 g: 0.1 g, Hong Kong, Australia and American Pharmaceutical Factory), 2 times a day, applied to affected area, continuous treatment for 8 weeks. The control group did not do any treatment. 3. The control group, the experimental group before treatment, the test group after treatment of fasting venous blood 3 ml in the morning, centrifuged supernatant, -20 鈩，
本文编号：2339289
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