中西医结合治疗小儿支原体肺炎及细胞因子变化

发布时间：2019-01-26 17:21

【摘要】：目的观察中西医结合治疗小儿支原体肺炎的疗效并探讨支原体肺炎患儿血清中细胞因子的变化。方法采用随机分组法,设立治疗组45例,口服中药加阿奇霉素10mg/(kgod)静脉点滴,对照组45例,单纯应用阿奇霉素静脉点滴,两组均以7d为1个疗程。并观察两组的有效率、症状体征消失时间及血清中白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子(TNF-α)的变化。结果两组的总有效率分别为93.33%和73.33%,治疗组疗效明显高于对照组(P0.05)。治疗组在发热消失时间、咳喘及罗音消失时间等方面都明显优于对照组(P0.05)。治疗组细胞因子水平明显低于对照组(P0.05)。结论中西医结合治疗小儿支原体肺炎能缩短病程,提高疗效,明显减轻患儿的痛苦,降低血清中细胞因子含量。
[Abstract]:Objective to observe the therapeutic effect of integrated traditional Chinese and western medicine on mycoplasma pneumonia in children and to explore the changes of serum cytokines in children with mycoplasma pneumonia. Methods A total of 45 patients in the treatment group were randomly divided into treatment group (n = 45) and control group (n = 45) by intravenous drip of azithromycin plus azithromycin. The two groups were treated with azithromycin for 7 days. The effective rate, the time of disappearance of symptoms and signs and the changes of serum interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor (TNF- 伪) were observed. Results the total effective rates of the two groups were 93.33% and 73.33% respectively. The curative effect of the treatment group was significantly higher than that of the control group (P0.05). The time of disappearance of fever, cough and wheezing in the treatment group was significantly better than that in the control group (P0.05). The level of cytokines in the treatment group was significantly lower than that in the control group (P0.05). Conclusion the treatment of mycoplasma pneumonia in children with combined Chinese and western medicine can shorten the course of disease, improve the curative effect, alleviate the pain of children, and reduce the content of cytokines in serum.
【作者单位】：湖南岳阳市二医院儿科;南方医科大学南方医院急诊科;
【分类号】：R725.6

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