帕金森病的中西医发病与免疫机制探讨
发布时间：2019-08-20 17:22
【摘要】：正气可体现遗传基因变异与多态性、炎症免疫等多种含义,同时在老龄、氧化应激等致病因素作用下,在正不胜邪、气虚则邪胜的情况下,致使致病因子即突触核蛋白(α-syn)病理产物聚集,导致帕金森病的发病表现出不同的个体差异与易感性,符合中医"正气存内,邪不可干"和"邪之所凑,其气必虚"理论精髓。外部环境毒理因素与内部免疫功能失调所致内风、痰热、瘀血,说明阴阳失其平衡、脏腑气血失调会影响到疾病的发生发展,正气的盛衰决定着某些致病因子的易感性及倾向性。同时,针灸与中药有效调节免疫机制等说明,中医所遵循的整体观念、辨证论治、君臣佐使的配伍原则本身就囊括了中医免疫治疗思想之精髓。
[Abstract]:Zhengqi can reflect genetic variation and polymorphism, inflammatory immunity and other meanings. At the same time, under the action of aging, oxidative stress and other pathogenic factors, under the action of pathogenic factors such as positive and evil, qi deficiency leads to the accumulation of pathological products of synaptic nucleoprotein (伪-syn), which leads to different individual differences and susceptibility to Parkinson's disease, which is in line with the "right qi storage, evil can not dry" and "evil". The essence of the theory that qi must be empty. External environmental toxicological factors and internal immune dysfunction caused by internal wind, phlegm-heat, blood stasis, indicating that yin and yang lose its balance, Zang-fu qi and blood disorder will affect the occurrence and development of the disease, the rise and fall of positive qi determines the susceptibility and tendency of some pathogenic factors. At the same time, acupuncture and traditional Chinese medicine effectively regulate the immune mechanism, which shows that the whole concept followed by traditional Chinese medicine, syndrome differentiation and treatment, the principle of compatibility between monarch and minister itself includes the essence of traditional Chinese medicine immunotherapy thought.
【作者单位】： 复旦大学附属金山医院中医科;南昌大学第三附属医院神经内科;
【分类号】：R742.5
[Abstract]:Zhengqi can reflect genetic variation and polymorphism, inflammatory immunity and other meanings. At the same time, under the action of aging, oxidative stress and other pathogenic factors, under the action of pathogenic factors such as positive and evil, qi deficiency leads to the accumulation of pathological products of synaptic nucleoprotein (伪-syn), which leads to different individual differences and susceptibility to Parkinson's disease, which is in line with the "right qi storage, evil can not dry" and "evil". The essence of the theory that qi must be empty. External environmental toxicological factors and internal immune dysfunction caused by internal wind, phlegm-heat, blood stasis, indicating that yin and yang lose its balance, Zang-fu qi and blood disorder will affect the occurrence and development of the disease, the rise and fall of positive qi determines the susceptibility and tendency of some pathogenic factors. At the same time, acupuncture and traditional Chinese medicine effectively regulate the immune mechanism, which shows that the whole concept followed by traditional Chinese medicine, syndrome differentiation and treatment, the principle of compatibility between monarch and minister itself includes the essence of traditional Chinese medicine immunotherapy thought.
【作者单位】： 复旦大学附属金山医院中医科;南昌大学第三附属医院神经内科;
【分类号】：R742.5
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