大肠癌组织中VEGF、MIF的表达及临床意义

发布时间：2018-01-07 12:18

本文关键词：大肠癌组织中VEGF、MIF的表达及临床意义　出处：《重庆医学》2015年11期 　论文类型：期刊论文

【摘要】：目的探讨大肠癌组织中血管内皮生长因子(VEGF)及人巨噬细胞游走抑制因子(MIF)的表达及临床意义。方法选取80份经手术切除并经病理证实为大肠癌的组织蜡块(观察组)及80份距癌肿边缘5cm以上经病理证实无癌细胞残存的正常大肠组织(对照组),SP法检测VEGF、MIF在大肠癌及正常大肠组织中的表达。结果VEGF,MIF在观察组中阳性率为77.50%、82.50%,在对照组阳性率为22.50%、27.50%,观察组阳性率明显高于对照组,差异有统计学意义(P0.05)。VEGF、MIF在大肠癌组织中的表达与肿瘤的浸润深度、淋巴结转移、临床分期相关,与性别、年龄、组织学分化无关。结论 VEGF、MIF在大肠癌组织中高表达。
[Abstract]:Objective to investigate the expression of vascular endothelial growth factor in colorectal cancer (VEGF) and human macrophage migration inhibitory factor (MIF) expression and its clinical significance. Methods a total of 80 cases of surgically and pathologically confirmed colorectal cancer tissues (observation group) and 80 cases of cancer from the edge of the 5cm with pathologically confirmed normal colorectal the organization has no residual cancer cells (control group), the detection of VEGF SP method, the expression of MIF in colorectal carcinoma and normal colorectal tissues. The results of VEGF, MIF in the observation group, the positive rate was 77.50%, 82.50%, 27.50% in the control group, the positive rate was 22.50%, the observation group was significantly higher than the control group, there was statistical significant differences (P0.05.VEGF), depth of invasion and tumor MIF expression in colorectal cancer tissues, lymph node metastasis, clinical stage, gender, age, histological differentiation. Conclusion VEGF, high expression of MIF in colorectal cancer tissues.

【作者单位】：安徽医科大学第一附属医院普外科;
【基金】：安徽省高等学校省级自然科学研究重点项目(KJ2011A155) 安徽省卫生厅医学科学研究基金(2010B007)
【分类号】：R735.34
【正文快照】： 大肠癌是常见的消化道恶性肿瘤之一,其发病率逐年上升,目前是位居中国第四的恶性肿瘤,与饮食习惯改变及缺乏运动有一定关系,发病高峰年龄为40~50岁,且有年轻化趋势。手术切除肿瘤及术后化疗是目前治疗大肠癌的主要方法,但大肠癌具有易复发、转移的特点,严重影响术后远期效果。

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