综述卵巢肿瘤干细胞耐药机制研究进展.pdf 全文

  本文关键词：肿瘤干细胞耐药机制研究进展，由笔耕文化传播整理发布。

国际妇产科学杂志 2011年 2月第 38卷第 1期 J Int Obstet Gynecol袁February 2011袁Vol. 38袁No.1 窑60窑 ?综 述? 卵巢肿瘤干细胞耐药机制研究进展 吴开元综述 史惠蓉审校 揖摘 要铱 卵巢癌治疗中的主要问题是高复发率和产生耐药性遥肿瘤干细胞具有无限增殖的能力袁对药 物的耐受性增加袁提示肿瘤干细胞与化疗耐药的关系密切遥从耐药卵巢癌细胞中可分选出具有特定表面标志 的肿瘤干细胞袁其为肿瘤形成提供可自我更新并在传代中保持肿瘤特性不变袁是卵巢癌耐药性产生和复发的 根本原因遥利用卵巢癌干细胞表面标志分子的特异性袁使化疗药物选择性地与卵巢癌干细胞结合袁彻底消除 肿瘤复发和耐药根源袁可为卵巢癌患者提供更有效的化疗方案遥 揖关键词铱 卵巢肿瘤曰 肿瘤干细胞曰抗药性袁肿瘤曰 生物学标记曰免疫曰多药耐药相关蛋白质类 Research Progress in Determing the Relationship Between Ovarian Cancer Stem Cells and Chemoresistance WU Kai -yuan, SHI Hui-rong. Department of Gynecology and Obstetrics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 揖Abstract铱 A major problem in the treatment of ovarian cancer is the high percentage of recurrence and chemoresistance. Cancer stem cells 渊CSCs冤 can proliferate indefinitely, be proved enhancing chemoresistance and indicatea close relationship with chemoresistance. CSCs with definite cell surface maker can be separated from chemoresistant ovarian cancer cells, they can providea reservoir of cells that can self -renew, maintain the tumor which make up the bulk of the tumor and may be the primary source of recurrence and chemoresistance. According to the special cell-surface marker and making chemotherapeutics selectively binding with ovarian cancer stem cells, can eliminate cancer recurrence and chemoresistance thoroughly and provide more effective che

  本文关键词：肿瘤干细胞耐药机制研究进展，由笔耕文化传播整理发布。