区域动脉灌注化疗栓塞联合全身静脉化疗治疗进展期胃癌的临床研究

发布时间：2018-01-12 03:26

  本文关键词：区域动脉灌注化疗栓塞联合全身静脉化疗治疗进展期胃癌的临床研究　出处：《现代消化及介入诊疗》2017年02期 　论文类型：期刊论文

  更多相关文章： 进展期胃癌 动脉灌注化疗栓塞 静脉化疗

【摘要】：目的研究区域动脉灌注化疗栓塞联合全身静脉化疗治疗进展期胃癌的临床疗效。方法选取我院2010年4月至2013年4月收治的82例进展期胃癌患者为研究对象,随机分为联合化疗组与静脉化疗组,每组41例。联合化疗组采用区域动脉灌注栓塞联合全身静脉化疗,静脉化疗组给予单纯全身静脉化疗,比较两组的临床疗效、肿瘤标志物含量、毒性反应以及生存率。结果联合化疗组的总缓解率、3年生存率分别为70.7%、68.3%,显著高于静脉化疗组的48.8%、46.3%(P0.05);联合化疗组治疗后的癌胚抗原(CEA)、糖链抗原72-4(CA72-4)、Ⅲ~Ⅴ度恶心呕吐、Ⅲ~Ⅴ度白细胞减少发生率分别为(15.22±4.18)μg/L、(28.46±9.17)U/mL、12.2%、4.9%显著低于静脉化疗组的(21.36±6.13)μg/L、(45.83±14.65)U/mL、31.7%、24.4%(P均0.05)。结论区域动脉灌注化疗栓塞联合全身静脉化疗治疗进展期胃癌患者,可以提高化疗药物效果,杀灭肿瘤细胞,缩小肿瘤体积,且毒副反应较小,患者耐受性好。
[Abstract]:Objective to study the clinical effect of regional arterial infusion chemoembolization combined with systemic intravenous chemotherapy in the treatment of advanced gastric cancer. Methods 82 patients with advanced gastric cancer from April 2010 to April 2013 in our hospital were selected. The subject of the study. The patients were randomly divided into combined chemotherapy group (n = 41) and intravenous chemotherapy group (n = 41). The combined chemotherapy group was treated with regional arterial infusion embolization combined with systemic intravenous chemotherapy, and the intravenous chemotherapy group was treated with simple systemic intravenous chemotherapy. Results the total remission rate and 3-year survival rate of the combined chemotherapy group were 70.7% and 68.3% respectively. It was significantly higher than that in intravenous chemotherapy group (48.8%) and 46.3% (P 0.05). The carcinoembryonic antigen (CEA), carbohydrate antigen (72-4) and CA72-4 (鈪，

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