8例临床级脐带间充质干细胞治疗放射性肺纤维化的观察

发布时间：2018-01-26 04:32

本文关键词： 脐带间充质干细胞放射性肺纤维化细胞治疗　出处：《第三军医大学学报》2017年10期 　论文类型：期刊论文

【摘要】：目的观察临床级脐带间充质干细胞(clinical grade umbilical cord mesenchymal stem cell,UC-MSC)治疗放射性肺纤维化(radiation-induced pulmonary fibrosis,RPF)的安全性和有效性。方法从2014年1月至2016年6月共入组8例RPF患者,其中2例乳腺癌,6例肺癌。通过支气管镜对RPF病灶部位灌洗后单次注入脐带间充质干细胞(1×10~6/kg),观察治疗前及治疗后第3天、3个月、6个月的临床症状、血液指标和圣乔治呼吸问卷(St George’s respiratory questionnaire,SGRQ)、6 min步行距离(six-minute walk distance,6MWD)、肺功能指标、相关炎症因子、CT肺密度的变化情况。结果 8例患者均能耐受UC-MSC治疗,6例患者自觉气促、咳嗽等症状有所好转,圣乔治呼吸问卷评分有差异(P0.05),血常规、C反应蛋白、肝肾功指标治疗前后无明显变化,转化生长因子-β1(transforming growth factor-β1,TGF-β1)在治疗后有下降趋势,但差异无统计学意义(P0.05),CT肺密度自身治疗前后比较有下降。结论 UC-MSC治疗RPF对患者的肝肾等主要脏器无损害,且能够减轻患者的临床症状和降低肺纤维化密度,但其确切的治疗效果及机制需更加严谨的研究进一步证实。
[Abstract]:Objective to observe clinical grade umbilical cord mesenchymal stem cell of umbilical cord mesenchymal stem cells. UC-MSCI was used to treat radiation-induced pulmonary fibrosis. Methods from January 2014 to June 2016, 8 patients with RPF were enrolled, 2 of them were breast cancer. Six cases of lung cancer were treated with bronchoscopy. Umbilical cord mesenchymal stem cells were injected with 1 脳 10 ~ (-6) / kg ~ (-1) 路kg ~ (-1) of umbilical cord mesenchymal stem cells by bronchoscopy. Before treatment and 3 days after treatment, 3 months after treatment were observed. Six months of clinical symptoms, blood indicators and St George's respiratory questionnaire questionnaire (St George's respiratory questionnaire SGRQ). 6 min walking distance from six-minute walk distension to 6MW DX, pulmonary function index, and related inflammatory factors. Results the changes of lung density in CT were all able to tolerate UC-MSC treatment in 6 patients with spontaneous shortness of breath and cough. The score of St. George's Respiratory questionnaire was significantly different (P 0.05). There was no significant change in serum C-reactive protein and liver and kidney function before and after treatment. Transforming growth factor- 尾 _ 1 was transformed into growth factor- 尾 _ 1. TGF- 尾 1) decreased after treatment, but the difference was not statistically significant (P 0.05). Conclusion UC-MSC can not damage the main organs such as liver and kidney, and can alleviate the clinical symptoms and reduce the density of pulmonary fibrosis. But its exact therapeutic effect and mechanism need to be further confirmed by more rigorous research.
【作者单位】：第三军医大学西南医院呼吸内科;第三军医大学西南医院老年科;
【基金】：中国科学院战略性先导专项项目(XDA 01030000)~~
【分类号】：R730.55
【正文快照】： 放射性肺损伤是在对胸部恶性肿瘤(肺癌、乳腺南医院和新桥医院放疗中心筛选放疗病人1 829例,癌、食管癌等)进行放射治疗时引起的肺组织损伤。根据纳入标准共入组8例RPF患者,患者具体筛选流根据放射性肺损伤发生在放疗后的时间不同分为:放程图见图1,其中2例乳腺癌,6例肺癌,年龄

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