肺鳞癌组织PD-L1表达变化及其与患者临床病理参数和预后的关系

发布时间：2018-01-27 02:00

  本文关键词： 肺鳞状细胞癌 程序性死亡配体 临床病理特征 预后　出处：《山东医药》2017年08期 　论文类型：期刊论文

【摘要】：目的探讨程序性死亡配体1(PD-L1)在肺鳞状细胞癌(简称肺鳞癌)发生、发展中的作用。方法选择肺鳞癌组织90例份、正常肺组织15例份,采用免疫组化法检测PD-L1表达,分析PD-L1表达与患者临床病理参数及预后的关系,应用Cox比例风险回归模型分析影响患者预后的危险因素。结果肺鳞癌组织PD-L1阳性表达率为66.67%(60/90),正常肺组织均为阴性表达,二者比较P0.01。肺鳞癌组织PD-L1阳性表达与患者性别、年龄、肿瘤直径、吸烟史无关(P均0.05),与p TNM分期、淋巴结转移有关(P均0.05)。PD-L1阳性表达者中位生存时间明显低于阴性表达者(P0.05)。Cox比例风险回归模型分析显示,PD-L1阳性、淋巴结转移、p TNM分期(Ⅲ期)是影响肺鳞癌预后的独立危险因素(P均0.05)。结论肺鳞癌组织PD-L1表达升高,其表达变化可促进肺鳞癌的进展和转移;检测PD-L1表达情况有助于判断患者预后。
[Abstract]:Objective to investigate the role of programmed death ligand (PD-L1) in the development and progression of squamous cell carcinoma of the lung. Methods 90 cases of lung squamous cell carcinoma and 15 cases of normal lung tissue were selected. The expression of PD-L1 was detected by immunohistochemistry, and the relationship between the expression of PD-L1 and clinicopathological parameters and prognosis was analyzed. Cox proportional risk regression model was used to analyze the risk factors influencing the prognosis of patients. Results the positive rate of PD-L1 expression in lung squamous cell carcinoma was 66.67 / 60 / 90). The positive expression of PD-L1 in lung squamous cell carcinoma was not correlated with sex, age, tumor diameter and smoking history (P 0.05). Stage with p TNM. The median survival time of patients with positive expression of P0. 05 and PD-L1 in lymph node metastasis was significantly lower than that in patients with negative expression. PD-L1 positive and lymph node metastasis (stage 鈪，

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