染发剂与非霍奇金淋巴瘤流行病学研究的Meta分析

发布时间：2018-01-27 17:39

本文关键词： 非霍奇金淋巴瘤染发剂使用系统评价 Meta分析　出处：《河南科技大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:综合评价及探讨染发剂使用与非霍奇金淋巴瘤相关发病风险的关系,以丰富对非霍奇金淋巴瘤病因学和流行病学的认识,为筛选和保护易感人群提供参考依据,同时为临床流行病预防工作开展提供依据。方法:以中文“非霍奇金淋巴瘤”、“淋巴瘤”、“染发剂”、“病例对照和(或)队列研究”、“危险因素”,英文以“(non-Hodgkin lymphoma OR Lymphoma OR NHL)AND(hair dye OR hair colorants OR hair coloring OR hair coloring agent OR hair color/colour)AND(risk OR incidence)AND(cohort OR case-control study)”以及同义词等为关键词,分别在中国学术期刊全文数据库、万方全文数据库和PubMed,the Cochrane Library以及Embase数据库进行检索,同时进行附加检索及手工检索补充,收集已发表的病例-对照研究。依据文献纳入标准筛选、纳入合格的文献,按照NOS量表对纳入文献的质量进行全面评价并提取相关资料。纳入以OR值及95%可信区间评价染发剂使用与NHL关系的病例对照研究及队列研究。纳入文献使用I2进行异质性,漏斗图Egger’s检验发表文献是否存在偏倚,应用RevMan 5.2软件和Stata 12.0软件对数据分析。结果:最终纳入16篇文章,其中13篇病例对照研究,3篇项队列研究。Meta分析结果显示,染发剂使用人群发生非霍奇金淋巴瘤的风险增加14%(OR=1.14 95%CI 1.01-1.29)。在病例对照研究OR值1.12(95%CI 0.99-1.26)及队列研究中1.16(95%CI 0.91-1.69)两者并无太大差异。亚组分析中女性使用者发生NHL的风险较男性增加;染发剂使用强度上,使用20年以上群体1.34(95%CI 1.04-1.92);地区之间同样存在差异。结论:染发剂使用增加NHL发病风险,尤其是使用时间及女性群体中,另外使用次数较多或者使用年限较久的人群因注意尽量减少暴露于染发剂产品。不过仍需要针对NHL亚型的研究来进一步评估染发剂使用的危害。
[Abstract]:Objective: to evaluate and explore the relationship between hair dye use and the risk of non-Hodgkin 's lymphoma in order to enrich the knowledge of etiology and epidemiology of non-Hodgkin 's lymphoma. To provide reference for screening and protection of susceptible populations and for the prevention of clinical epidemic. Methods: Chinese "non-Hodgkin 's lymphoma", "lymphoma", "hair dye". "Case-control and / or cohort study", "risk factors". "non-Hodgkin lymphoma OR Lymphoma OR NHLLAND' Hair dye OR hair colorants OR hair coloring OR hair coloring agent OR. Hair color / colour). "AND(risk OR OR OR case-control study" and synonyms are keywords. The full text databases of Chinese academic journals, Wanfang full-text database, PubMedthe Cochrane Library and Embase database were searched respectively. At the same time, additional retrieval and manual retrieval were carried out to collect published case-control studies. According to the NOS scale, the quality of the literature was comprehensively evaluated and relevant data were extracted. A case-control study and a cohort study were conducted to evaluate the relationship between hair dye use and NHL with OR value and 95% confidence interval. I2 was used for heterogeneity in the literature. The data were analyzed by RevMan 5.2 software and Stata 12.0 software. Results: 16 articles were included. Among them, 13 case-control studies and 3 cohort studies. Meta-analysis results showed. The risk of non-Hodgkin 's lymphoma was increased by 1.14 95 CI 1.01-1.29 and OR 1.12 in the case-control study. 95 CI 0.99-1.26) and in the cohort study 1.16 / 95 CI 0.91-1.69). There was no significant difference between the two groups. In subgroup analysis, the risk of NHL among female users was higher than that of men. The intensity of hair dyeing agent was 1.3495 CI 1.04-1.92 in the group of more than 20 years; Conclusion: hair dye use increases the risk of NHL, especially in women and women. In addition, people who use more frequently or for a longer period of time take care to minimize exposure to hair dye products. However, a study of NHL subtypes is needed to further assess the harm of hair dye use.
【学位授予单位】：河南科技大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R733.1

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