血清硒水平和尿碘水平对甲状腺癌患病的影响研究

发布时间：2018-01-28 04:36

本文关键词： 甲状腺肿瘤硒碘影响因素分析　出处：《中国全科医学》2017年34期 　论文类型：期刊论文

【摘要】：目的探讨血清硒水平和尿碘水平对甲状腺癌患病的影响。方法选取2014年3—12月新疆医科大学第二附属医院血管甲状腺外科收治的甲状腺癌患者153例、甲状腺良性结节患者154例,并于同期在本院选取甲状腺形态正常的健康体检者327例。比较3组的性别、年龄、血清甲状腺功能及自身抗体指标水平、血清硒水平及尿碘水平,并采用多元逐步Logistic回归分析探讨性别、年龄、血清硒水平及尿碘水平对甲状腺癌患病的影响。结果 3组性别、年龄及血清总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、促甲状腺素(TSH)、甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体(TPOAb)水平比较,差异有统计学意义(P0.05)。3组血清硒水平和尿碘水平比较,差异有统计学意义(P0.05)。其中,甲状腺形态正常组血清硒水平优于甲状腺良性结节组,甲状腺良性结节组血清硒水平优于甲状腺癌组,差异有统计学意义(P0.05);甲状腺形态正常组、甲状腺良性结节组尿碘水平优于甲状腺癌组,差异有统计学意义(P0.05);而甲状腺形态正常组与甲状腺良性结节组尿碘水平比较,差异无统计学意义(P0.05)。多元逐步Logistic回归分析结果显示,性别、血清硒水平、尿碘水平是甲状腺癌患病的影响因素。结论女性、低血清硒水平、高尿碘水平是甲状腺癌患病的危险因素。
[Abstract]:Objective to investigate the effect of serum selenium level and urinary iodine level on thyroid cancer. Methods 153 patients with thyroid cancer were selected from 2014 to December in the second affiliated Hospital of Xinjiang Medical University. ... 154 patients with benign thyroid nodules and 327 healthy persons with normal thyroid shape were selected in the same period. Sex, age, serum thyroid function and autoantibody level were compared among the three groups. The effect of sex, age, serum selenium level and urinary iodine level on thyroid cancer was studied by multiple stepwise Logistic regression analysis. Age and serum total triiodothyronine (TTC), total thyroxine (TT4), thyrotropin (TSH), thyroglobulin antibody (TGAb). The levels of serum selenium and urine iodine in group P0.053.were significantly different from those in the group of anti-thyroid peroxidase antibody (TPOAb). The serum selenium level in the normal thyroid shape group was better than that in the benign thyroid nodule group, and the serum selenium level in the thyroid benign nodule group was better than that in the thyroid carcinoma group. The difference was statistically significant (P 0.05). The level of urinary iodine in the thyroid benign nodule group was higher than that in the thyroid carcinoma group, and the difference was statistically significant (P 0.05). There was no significant difference in urinary iodine level between normal thyroid shape group and benign thyroid nodule group (P 0.05). Multiple stepwise Logistic regression analysis showed that sex. Conclusion low serum selenium level and high urinary iodine level are risk factors for thyroid cancer in women.
【作者单位】：新疆医科大学第二附属医院内分泌科;
【基金】：新疆维吾尔自治区自然科学基金资助项目(2013211A057)——乌鲁木齐地区碘和硒营养状态与甲状腺癌的相关性研究
【分类号】：R736.1
【正文快照】： 在过去的30年中甲状腺癌的发病率增加了3倍[1]。腺球蛋白抗体(TGAb,参考范围0~115 U/ml)、抗甲国家提倡食盐加碘政策,人群碘营养状态得到了很大改状腺过氧化物酶抗体(TPOAb,参考范围0~34 U/ml)。善,但甲状腺疾病谱也发生了较大变化[2]。既往研究结1.2.2血清硒水平检测抽取空腹

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