扩散峰度成像在脑胶质瘤分级中的应用价值:Meta分析

发布时间：2018-01-28 05:18

本文关键词： 扩散峰度成像脑胶质瘤分级 Meta分析　出处：《临床放射学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的采用Meta分析方法综合定量评价扩散峰度成像在脑胶质瘤分级中的应用价值。方法检索Cochrane协作网、Cochrane图书馆、Pubmed、OVID、中文科技期刊全文数据库(CNKI)、万方数据知识服务平台、维普中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)自建库以来至2016年5月国内外公开发表的关于扩散峰度成像在脑胶质瘤分级中应用的中英文文献。按照Cochrane协作网推荐的诊断试验纳入标准筛选文献,采用QUADAS条目评价纳入研究的质量,提取纳入研究的相关数据信息。采用Meta-Disc 1.4软件进行数据分析,通过Meta分析合并诊断效应量及绘制汇总受试者工作特征曲线(SROC曲线),计算曲线下面积(AUC)。结果共纳入5篇文献,研究病灶共265个,汇总加权敏感度、特异度、诊断比值比、阳性似然比、阴性似然比及95%可信区间分别为0.88(95%CI 0.81~0.93)、0.87(95%CI 0.81~0.91)、52.49(95%CI17.36~158.67)、6.25(95%CI 3.17~12.32)、0.16(95%CI 0.08~0.36);SROC曲线AUC为0.9439。结论扩散峰度成像在脑胶质瘤分级中具有很高的应用价值。
[Abstract]:Objective to evaluate the application value of diffusion kurtosis imaging (DKI) in glioma grading by Meta analysis. Methods the Cochrane Library was searched by Cochrane Cochrane Library. Pubmeda OVID, CNKIN, Wancang data knowledge Service platform, Weipu Chinese Sci-tech Journals Database (VIPs). China Biomedical Literature Database (CBM). The Chinese and English literature on the application of diffusion kurtosis imaging in glioma grading has been published since May 2016. According to the diagnostic criteria recommended by Cochrane Cooperative Network. Screening the literature. QUADAS items were used to evaluate the quality of the study, and the relevant data information was extracted. The data was analyzed by Meta-Disc 1.4 software. The Meta analysis was used to analyze the diagnostic effect and to draw the operating characteristic curve of the subjects. The area under the curve was calculated. The results were included in 5 articles. A total of 265 lesions were studied, including weighted sensitivity, specificity, diagnostic ratio and positive likelihood ratio. The negative likelihood ratio and 95% confidence interval were 0.8895 CI 0.81C 0.93 and 0.8795 CI 0.81 卤0.91 respectively. 52.49 / 95 / CI 17.36 / 158.67 / 6.25 / 95 / CI 3.17 / 12.32 / 0.1695 / CI 0.080.36; The AUC of SROC curve is 0.9439.Conclusion Diffusion kurtosis imaging has high value in glioma grading.
【作者单位】：暨南大学附属第一医院医学影像中心;
【分类号】：R445.2;R739.41
【正文快照】： 胶质瘤是成年人最常见的颅内原发性肿瘤,中枢神经系统WHO分类指南中指出,评估肿瘤的治疗与预后需要结合患者年龄大小、肿瘤生长部位、侵犯范围、生长速度等情况,但术前肿瘤的准确分级对手术方式选择、切除范围及预后判断具有重要意义[1]。扩散峰度成像(diffusion kurtosis ima

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