青海地区2型糖尿病伴发消化系统恶性肿瘤的临床特点分析

发布时间：2018-01-29 06:22

本文关键词： 2型糖尿病消化系统恶性肿瘤临床特点　出处：《青海大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:了解2型糖尿病(Type2 Diabetes Mellitus,T2DM)伴发消化系统恶性肿瘤(Digestive system carcima,DSC)的临床特点。方法:分组:从2009年4月至2016年10月在青海大学附属医院住院的10468例T2DM患者中筛选出T2DM伴DSC患者242例作为合并组;随机抽取同期单纯T2DM患者100例为糖尿病组；随机抽取同期在青海大学附属医院住院的单纯消化系统恶性肿瘤患者101例作为肿瘤组。通过查阅患者的病历,收集患者的临床信息,进行回顾性分析。统计学处理:所有数据用SPSS21.0统计软件进行统计分析。结果:1、在青海地区,T2DM伴发DSC在10468例T2DM患者中的的检出率为2.31%,其构成为:肠癌占首位(41.3%),其次为胃癌(35.5%),在男性患者中,胃癌(38.8%)和肠癌(38.25%)的构成基本一致,女性患者胃癌占首位(50.85%),其次为肠癌(25.42%)。2、一般临床资料的比较:合并组分别与肿瘤组、糖尿病组在年龄的比较有统计学意义(P0.05)。3、生化指标结果的比较:合并组分别与肿瘤组、糖尿病组在GLU、CR、TC、LDL的比较有统计学意义(P0.05)。4、CEA、CA199 ROC曲线下面积分别为0.433,0.437。5、用Fisher二分类判别法建立方程,诊断T2DM伴发DSC的正确率达76.1%。结论:1、青海地区的2型糖尿病伴发消化系统恶性肿瘤的检出率为2.31%,其构成,以结肠癌占首位最为多见,其次为胃癌;在男性患者胃癌占首位,而女性患者中肠癌占首位。2、青海地区的2型糖尿病伴发消化系统恶性肿瘤的患者既有2型糖尿病的特征,也有肿瘤的特征,表现在:(1)发病年龄高。(2)血脂、血糖紊乱,伴有贫血和营养不良。3、CEA、CA199单独检测对2型糖尿病伴发消化系统恶性肿瘤诊断价值偏低。4、利用Fisher二分类判别法建立的方程对2型糖尿病伴发消化系统肿瘤的诊断可能有一定帮助。
[Abstract]:Objective: to investigate Type2 Diabetes Mellitus in type 2 diabetes mellitus. T2DM) was associated with digestive system malignant system carcima. DSC). Methods: group:. From April 2009 to October 2016, a total of 10468 T2DM patients with DSC were selected from the affiliated Hospital of Qinghai University as the combined group. 100 patients with T2DM were randomly selected as diabetic group. A total of 101 patients with simple digestive system malignant tumors in Qinghai University affiliated Hospital were randomly selected as tumor group. The clinical information of the patients was collected by consulting the patient's medical records. Retrospective analysis. Statistical processing: all data were analyzed by SPSS21.0 statistical software. Results: 1, in Qinghai. The positive rate of T2DM with DSC was 2.31 in 10468 patients with T2DM. In male patients, the composition of gastric cancer 38.8% and intestinal cancer 38.25) was basically the same. In female patients, stomach cancer accounted for the first 50.85%, followed by intestinal cancer 25.42%. Comparison of general clinical data: the combined group and tumor group, diabetes group in the comparison of age has statistical significance (P0.05. 3) comparison of biochemical indicators: the combined group and tumor group respectively. The area under the ROC curve of CA _ (199) was 0.433 in the diabetic group. There was significant difference between the two groups (P < 0.05). The equation was established by Fisher two-classification discriminant method. The correct rate of diagnosis of T2DM accompanied with DSC was 76.1. conclusion 1. The detection rate of type 2 diabetes with digestive system malignant tumor in Qinghai area was 2.31. Colon cancer was the most common, followed by gastric cancer. Gastric cancer is the most common in male patients, while intestinal cancer is the first in female patients. Type 2 diabetes mellitus with digestive system malignant tumor in Qinghai area has the characteristics of type 2 diabetes, but also has the characteristics of tumor. It is manifested in 1) the age of onset is high. (2) Blood lipid, blood sugar disorder, accompanied by anemia and malnutrition. 3CEA. The diagnostic value of CA199 alone for type 2 diabetes with digestive system malignancy was low. The equation established by Fisher two-classification discriminant method may be helpful for the diagnosis of type 2 diabetes mellitus complicated with digestive system tumor.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735;R587.1

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