恒定自然杀伤T细胞与肿瘤免疫治疗

发布时间：2018-01-31 14:42

本文关键词： 恒定自然杀伤T细胞肿瘤免疫治疗临床应用　出处：《中国生物化学与分子生物学报》2017年05期 　论文类型：期刊论文

【摘要】：恒定自然杀伤T细胞(i NKT)是T淋巴细胞的一个独特亚群,兼具自然杀伤(NK)细胞和T细胞特征,同时表达T细胞受体(TCR)和NK细胞表面标志。i NKT细胞被激活后,通过分泌细胞因子,活化其它免疫细胞参与先天性免疫和获得性免疫,在抗肿瘤免疫过程中发挥调节作用。在多种癌症患者体内,发现外周血中i NKT细胞的数量降低、功能减弱,进而导致临床治疗效果不佳。近年来,基础研究和早期临床试验结果表明,注射抗原递呈细胞或/和体外培养并活化的i NKT细胞,抗肿瘤免疫治疗效果显著。本文就i NKT细胞的分类及生物学特性,在肿瘤免疫治疗中的作用与其机制,以及其临床应用等进行综述。
[Abstract]:Invariant natural killer T cells (NKT) is a unique subgroup of T lymphocytes, which has the characteristics of natural killer NK cells and T cells. After activation of T cell receptor (TCR) and NK cell surface marker. I NKT cells secreted cytokines and activated other immune cells to participate in congenital and acquired immunity. In many kinds of cancer patients, the number and function of I NKT cells in peripheral blood were decreased, which resulted in poor clinical treatment in recent years. The results of basic research and early clinical trials showed that antigen-presenting cells were injected or / and I NKT cells were cultured and activated in vitro. The effect of anti-tumor immunotherapy is remarkable. This article reviews the classification and biological characteristics of I NKT cells, its role and mechanism in tumor immunotherapy, and its clinical application.
【作者单位】：浙江大学转化医学研究院;
【分类号】：R730.51
【正文快照】： *联系人Tel:0571-86971697;E-mail:yibingxu@zju.edu.cnReceived:December 15,2016;Revised:February 4,2017;Accepted:February 8,2017*Corresponding author Tel:0571-86971697;E-mail:yibingxu@zju.edu.cn肿瘤的发生发展与机体的免疫功能之间关系密切[1,2]。淋巴细胞作为一

【相似文献】