PARP在乳腺癌中的表达与临床病理特征及预后相关性的Meta分析

发布时间：2018-02-03 01:33

本文关键词： 乳腺癌聚腺苷二磷酸核糖聚合酶预后 meta分析　出处：《吉林大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:对聚腺苷二磷酸核糖聚合酶在乳腺癌组织中的表达与临床病理特征及预后的相关性进行Meta分析。方法:从Pubmed、Web of Science、Embase、The Cochrane Library、中国学术期刊全文数据库、中国生物医学文献数据库和万方数据库中,检索时间均由建库开始到2016年12月20日,检索有关聚腺苷二磷酸核糖聚合酶在乳腺癌组织中的表达与生存分析数据相关的文献,由两位研究者独立地筛选所有检索到的文献。运用风险比(hazard ratio,HR)评价聚腺苷二磷酸核糖聚合酶表达与乳腺癌无病生存和总生存的相关性,采用相对危险度(relative risk,RR)评价聚腺苷二磷酸核糖聚合酶表达与乳腺癌临床病理特征中核分级、三阴性乳腺癌、年龄、肿瘤大小、淋巴结是否转移、BRCA1、ER、PR、HER2、Ki67状态和pCR的相关性。结果:纳入8篇文献,共计3506例乳腺癌患者。Meta分析结果显示:(1)聚腺苷二磷酸核糖聚合酶在早期乳腺癌中的过表达是不良预后因素,其中无病生存的HR为3.08(95%CI,1.14-8.29,P=0.03),总生存的HR为1.82(95%CI,1.20-2.76;P=0.005);(2)聚腺苷二磷酸核糖聚合酶过表达与乳腺癌高级别核分级显著相关(RR=1.34;95%CI,1.10-1.63;P=0.004),在三阴性乳腺癌中表达增高(RR=1.37;95%CI,1.06-1.77;P=0.02);(3)聚腺苷二磷酸核糖聚合酶在乳腺癌中的过表达与年龄、肿瘤大小、淋巴结是否转移、BRCA1、ER、PR、HER2、Ki67状态和pCR都无相关性。结论:1、聚腺苷二磷酸核糖聚合酶在早期乳腺癌中的过表达是不良预后的因素。2、聚腺苷二磷酸核糖聚合酶在乳腺癌中的过表达与高级别核分级及三阴性乳腺癌相关。3、聚腺苷二磷酸核糖聚合酶在乳腺癌中的过表达与年龄、肿瘤大小、淋巴结是否转移、BRCA1、ER、PR、HER2、Ki67状态和pCR都无相关性。
[Abstract]:Objective: to analyze the correlation between the expression of polyadenosine diphosphate ribose polymerase and clinicopathological features and prognosis of breast cancer by Meta. Methods: from Pubmed. Web of Science Embase the Cochrane Library, full text Database of Chinese academic Journals. In the Chinese Biomedical Literature Database and Wanfang Database, the retrieval time is from the beginning of the database construction to December 20th 2016. To search the literature about the expression of polyadenosine diphosphate ribose polymerase in breast cancer tissues and survival analysis data. The two researchers independently sifted through all the retrieved literature using a risk ratio of hazard ratio. HRA was used to evaluate the correlation between the expression of polyadenosine diphosphate polymerase and the disease-free survival and total survival of breast cancer. The relative risk was used to evaluate the expression of polyadenosine diphosphate polymerase. RR) was used to evaluate the expression of polyadenosine diphosphate polymerase and the clinical pathological features of breast cancer, including nuclear grade, age, tumor size and lymph node metastasis. The correlation between the status of HER2 and Ki67 and pCR. Results: eight articles were included. A meta-analysis of 3506 breast cancer patients showed that the overexpression of polyadenosine diphosphate polymerase in early breast cancer was a poor prognostic factor. The HR of disease-free survival was 3.08 ~ 9.95% and the total surviving HR was 1.82 ~ 95% ~ 1.20-2.76; P0. 005; (2) the overexpression of polyadenosine diphosphate polymerase was significantly correlated with the high grade nuclear grade of breast cancer. 95 CII 1.10-1.63; In triple-negative breast cancer, the expression of PnP 0.004 was higher than that of RRN 1.37; 95CIN 1.06-1.77; P0. 02; (3) overexpression of polyadenosine diphosphate polymerase in breast cancer, age, tumor size, lymph node metastasis, PRHER2. There was no correlation between Ki67 status and pCR. Conclusion the overexpression of polyadenosine diphosphate polymerase in early breast cancer is a factor of poor prognosis. The overexpression of polyadenosine diphosphate ribose polymerase in breast cancer was associated with high grade nuclear grade and triple negative breast cancer. The overexpression of polyadenosine diphosphate ribose polymerase in breast cancer was associated with age and tumor size. There was no correlation between the status of PRER2 and Ki67 and pCR.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.9

【相似文献】