241例多发性骨髓瘤器官损害的临床分析

发布时间：2018-02-03 04:23

本文关键词： 多发性骨髓瘤器官损害肾损害骨损害贫血高钙血症　出处：《广西医科大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：探讨多发性骨髓瘤器官损害的发病情况及其与多发性骨髓瘤的类型、临床分期分组及疗效的关系。方法：回顾性分析2010年8月至2015年8月间至广西医科大学附属第一医院住院的241例多发性骨髓瘤患者的临床资料。结果：①肾损害中男性发生率高于女性(48.7%vs.28.9%,P=0.003)。②71-80岁多发性骨髓瘤组肾损害发生率显著高于41-50岁组、51-60岁组、61-70岁组(92.3% vs.12.2%、40.3%、42.1%,P均0.01)。③IgG型多发性骨髓瘤组骨损害发生率显著高于轻链型组和IgA组(95.0% vs.75.8%、84.4%,P均0.05)。④轻链型多发性骨髓瘤组贫血发生率显著高于IgG组及IgA组(78.8% vs.60.0%、51.3%,P均0.05)；⑤B组多发性骨髓瘤高钙血症发生率显著高于A组(10.9% vs.4.3%,P0.05)。结论：①肾损害在男性患者高发；②肾损害在老年患者高发;③骨损害在IgG型患者高发；④贫血在轻链型患者高发；⑤高钙血症在B组患者高发。
[Abstract]:Objective: to investigate the incidence of multiple myeloma and the types of multiple myeloma. The relationship between clinical staging and curative effect. Methods:. The clinical data of 241 patients with multiple myeloma from August 2010 to August 2015 in the first affiliated Hospital of Guangxi Medical University were analyzed retrospectively. 1the incidence of renal damage in males was higher than that in females (. 48.7vs.28.9%. The incidence of renal damage in multiple myeloma group aged from 271-80 years old was significantly higher than that in patients aged 41-50 years old or 51-60 years old. 92.3% vs.12.2% in 61-70 years old group, 42.1% in 40.3%. The incidence of bone damage in patients with multiple myeloma group (P < 0.01) was significantly higher than that in patients with light chain type and IgA group (95.0% vs 75.8%, 84.4%). The incidence of anemia in light chain multiple myeloma group was significantly higher than that in IgG group and IgA group (78.8% vs 60.0%). 5The incidence of hypercalcemia of multiple myeloma in group B was significantly higher than that in group A (10.9% vs.4.3). (2) the incidence of renal damage was high in elderly patients; 3The incidence of bone damage was high in patients with IgG type; 4High incidence of anemia in patients with light chain type; 5 the incidence of hypercalcinemia was high in group B.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R733.3

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