血清E-cadherin在甲状腺乳头状癌中的表达及意义

发布时间：2018-02-03 04:08

本文关键词： 甲状腺乳头状癌血清 E-钙黏连蛋白　出处：《临床耳鼻咽喉头颈外科杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的:通过对甲状腺乳头状癌、结节性甲状腺肿患者及正常人群血清E-cadherin浓度的测定,结合E-cadherin蛋白在乳头状癌、结节性甲状腺肿和癌旁正常组织中的检测,分析E-cadherin在甲状腺乳头状癌中的作用及意义。方法:采用ELISA法检测E-cadherin在86例甲状腺乳头状癌、16例结节性甲状腺肿患者和10例正常人血清中的含量,并分析其与甲状腺乳头状癌临床病理特征的关系;应用Western Blot法检测E-cadherin蛋白在甲状腺乳头状癌、结节性甲状腺肿和癌旁正常组织中的含量。结果:甲状腺乳头状癌患者血清E-cadherin的含量明显高于结节性甲状腺肿患者和正常人(P0.05),结节性甲状腺肿和正常人血清中E-cadherin的含量无明显差异(P0.05)。E-cadherin蛋白在乳头状癌组织中的含量明显低于结节性甲状腺肿、癌旁组织(P0.05),结节性甲状腺肿、癌旁组织中含量无明显差异(P0.05)。血清中E-cadherin的高水平表达与甲状腺乳头状癌的临床病理分期和淋巴结转移相关(P0.05),而与患者的性别、年龄及肿瘤直径大小不相关(P0.05)。结论:血清E-cadherin上调与甲状腺乳头状癌的临床病理分期和远处淋巴结转移相关。患者血清中E-cadherin含量的检测,在甲状腺乳头状癌诊疗及预后方面具有重要意义。
[Abstract]:Objective: to determine the serum E-cadherin concentration in patients with papillary thyroid carcinoma, nodular goiter and normal people, and to combine E-cadherin protein in papillary carcinoma. Detection of nodular goiter and adjacent normal tissue. To analyze the role and significance of E-cadherin in thyroid papillary carcinoma. Methods: E-cadherin was detected in 86 cases of papillary thyroid carcinoma by ELISA method. The contents of serum in 16 patients with nodular goiter and 10 normal controls were analyzed and their relationship with clinicopathological features of papillary thyroid carcinoma was analyzed. E-cadherin protein was detected by Western Blot in thyroid papillary carcinoma. Results: serum E-cadherin levels in patients with thyroid papillary carcinoma were significantly higher than those in patients with nodular goiter and normal controls (P 0.05). . There was no significant difference in E-cadherin levels between nodular goiter and normal controls (P0.05). The content of E-cadherin protein in papillary carcinoma was significantly lower than that in nodular goiter. Paracancerous tissue (P0.05), nodular goiter. There was no significant difference in the content of E-cadherin in paracancerous tissues. The high expression of E-cadherin in serum was correlated with the clinicopathologic stage and lymph node metastasis of papillary thyroid carcinoma (P0.05). And the sex of the patient. Age and tumor diameter were not correlated with P0.05). Conclusion: the up-regulation of serum E-cadherin is related to the clinicopathologic stage and distant lymph node metastasis of papillary thyroid carcinoma. It is of great significance in the diagnosis, treatment and prognosis of papillary thyroid carcinoma.
【作者单位】：河北北方学院人体解剖学教研室;河北北方学院组织胚胎学教研室;
【基金】：河北省教育厅青年基金(No:QN2015204);河北省教育厅重点项目(No:ZD2016094) 河北省卫生厅医学研究课题(No:20130035) 河北省重大医学科研课题(No:ZD2013052) 河北北方学院青年基金项目(No:Q2014020)
【分类号】：R736.1
【正文快照】： 甲状腺癌在头颈部恶性肿瘤中居首位,甲状腺乳头状癌(papillary thyroid cancer,PTC)是甲状腺癌中最常见的病理类型,占甲状腺癌的70%~80%〔1〕,其发病较隐匿,早期无明显症状,与良性肿瘤很难区分,且发生淋巴结转移早。甲状腺癌新增病例以微小癌(papillary thyroid microcarcinom

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