拉伸指数与单指数模型多b值DWI定量参数在胰腺癌的对照研究

发布时间：2018-02-03 23:00

本文关键词： 胰腺癌拉伸指数模型扩散加权成像标准化表观扩散系数分布扩散系数扩散异质性指数　出处：《临床放射学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨拉伸指数与单指数模型多b值磁共振扩散加权成像(DWI)定量参数在胰腺癌的应用价值。方法搜集临床或手术证实的37例胰腺癌患者,应用GE Discovery MR750 3.0T磁共振扫描仪对所有患者行胰腺多b值DWI。应用MADC软件的单指数和拉伸指数模型分析多b值DWI,得到标准化表观扩散系数(ADC_(standard))、分布扩散系数(DDC)和扩散异质性指数(α)参数图,测量胰腺癌和癌周胰腺组织的ADC_(standard)、DDC和α值,并应用独立样本t检验进行统计学分析。结果胰腺癌的DDC值明显低于癌周胰腺组织的DDC值(1.244×10~(-3)mm~2/s vs.1.679×10~(-3)mm~2/s,P=0.013),胰腺癌的α值明显高于癌周胰腺组织的α值(0.720 vs.0.653,P=0.019),差异均有统计学意义。DDC和α值鉴别胰腺癌和癌周胰腺组织的受试者工作特征曲线(ROC)曲线下面积分别为0.640、0.631。胰腺癌的DDC值和ADC_(standard)值显著正相关(r=0.401,P=0.013);α值和ADC_(standard)值显著正相关(r=0.360,P=0.026)。结论拉伸指数模型DWI相关参数DDC和α可以鉴别胰腺癌和癌周胰腺组织,DDC鉴别胰腺癌和癌周胰腺组织时较α的诊断效能更高。
[Abstract]:Objective to investigate the value of DWI quantitative parameters of multiple b value Mr diffusion weighted imaging (DWI) in the diagnosis of pancreatic cancer. Methods 37 patients with pancreatic cancer were collected. Application of GE Discovery MR750. A 3.0T magnetic resonance scanner was performed on all patients with multiple b-value DWIs. Multiple b-valued DWI was analyzed by single index and stretch index models of MADC software. The standard apparent diffusion coefficient (ADCD), the distributed diffusion coefficient (DDCC) and the diffusion heterogeneity index (伪) parameters are obtained. The DDC and 伪 values of pancreatic carcinoma and pericancerous pancreatic tissues were measured. Results the DDC value of pancreatic carcinoma was significantly lower than that of pericancerous pancreatic tissue (DDC = 1.244 脳 10 ~ (-3)). Mm~2/s vs.1.679 脳 10 ~ (-3) mm ~ (-1) / s. The 伪 value of pancreatic carcinoma was significantly higher than that of pericancerous pancreatic tissue (0.720 vs.0.653P0. 019). The difference was statistically significant. DDC and 伪 values were used to distinguish the area under the operating characteristic curve of pancreatic cancer and pericancerous pancreatic tissues, and the area under the curve was 0.640, respectively. There was a significant positive correlation between the DDC value and the ADCS standard value of pancreatic cancer. There was a significant positive correlation between 伪 value and ADCS standard value. Conclusion DDC and 伪 are more effective in differentiating pancreatic carcinoma from pericancerous pancreatic tissue than 伪 in differentiating pancreatic carcinoma from pericancerous pancreatic tissue.
【作者单位】：空军军医大学西京医院放射科;
【基金】：国家自然科学基金重大国际(地区)合作与交流项目(编号:81220108011);国家自然科学基金青年面上连续项目(编号:81370039)
【分类号】：R445.2;R735.9
【正文快照】： 本研究系国家自然科学基金重大国际(地区)合作与交流项目(编号:81220108011);国家自然科学基金青年面上连续项目(编号:81370039)作者单位:710032西安,空军军医大学西京医院放射科;*通讯作者马婉玲,魏梦绮,任静,张劲松,潘奇,侯炜寰,张广文,文娣娣,仲津漫,宦怡*胰腺癌预后很差,

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