非小细胞肺癌中lncRNA MVIH与吉西他滨耐药的相关性研究

发布时间：2018-02-09 18:53

  本文关键词： 癌 非小细胞肺 吉西他滨 抗药性 肿瘤 长链非编码RNA　出处：《重庆医学》2017年07期 　论文类型：期刊论文

【摘要】：目的探讨非小细胞肺癌(NSCLC)组织中长链非编码RNA MVIH(lncRNA MVIH)与吉西他滨耐药的相关性。方法将56例NSCLC患者分为观察组(n=30)和对照组(n=26),观察组给予吉西他滨/顺铂(GP)治疗方案;对照组给予紫杉醇/顺铂(TP)治疗方案,两组患者均以21d为1个治疗周期;2个周期后进行疗效评价。提取获得标本的RNA,对lncRNA MVIH的表达进行荧光定量分析。结果观察组30例患者中化疗敏感13例,化疗耐药10例;耐药组lncRNA MVIH的表达水平为3.61±0.50,显著高于敏感组(2.08±0.27),差异有统计学意义(P0.05)。对照组26例患者中化疗敏感9例,化疗耐药9例;耐药组lncRNA MVIH表达水平为2.94±0.31,敏感组为2.77±0.34,两组比较差异无统计学意义(P0.05)。结论NSCLC组织中lncRNA MVIH水平与吉西他滨耐药有关,提示lncRNA MVIH可作为预测吉西他滨耐药的标志物。
[Abstract]:Objective to investigate the relationship between RNA MVIH(lncRNA MVIH and gemcitabine resistance in non-small cell lung cancer (NSCLC) tissues. Methods 56 patients with NSCLC were divided into observation group (n = 30) and control group (n = 26). The study group was treated with gemcitabine / cisplatin. The control group was treated with paclitaxel / cisplatin and TP1. The therapeutic effect was evaluated after 2 cycles. The expression of lncRNA MVIH was analyzed quantitatively by fluorescence. Results in the observation group, 13 cases were chemosensitivity and 10 cases were chemotherapeutic resistance. The expression level of lncRNA MVIH in resistant group was 3.61 卤0.50, which was significantly higher than that in sensitive group (2.08 卤0.27), the difference was statistically significant (P 0.05). In the control group, 9 cases were chemosensitivity and 9 cases were chemoresistance. The expression level of lncRNA MVIH was 2.94 卤0.31 in drug resistant group and 2.77 卤0.34 in sensitive group. There was no significant difference between the two groups (P 0.05). Conclusion the level of lncRNA MVIH in NSCLC tissue is related to gemcitabine resistance, suggesting that lncRNA MVIH can be used as a marker for predicting gemcitabine resistance.
【作者单位】： 无锡卫生高等职业技术学校护理系;
【基金】：无锡市医院管理中心科研项目(YGZXM14021)
【分类号】：R734.2
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本文编号：1498625