肿瘤标志物CA724、CA199、CA242、CEA联合检测在老年胃癌诊断中的应用

发布时间：2018-02-12 07:34

  本文关键词： 胃癌 CA CA CA CEA 肿瘤标志物　出处：《中国老年学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的观察肿瘤标志物CA724、CA199、CA242、CEA单项及联合检测在老年胃癌诊断中的价值。方法选取老年胃癌患者50例作为观察组,同时选取慢性萎缩性胃炎伴重度不典型增生的患者50例为对照1组,选取浅表性胃炎或正常胃黏膜者50例作为对照2组。检测三组观察对象的血清,上午取空腹静脉血10 ml,用离心机分离,然后将分离血清存贮在-90℃的冷冻冰箱进行保存,最后进行肿瘤标志物CA724、CA199、CA242、CEA检测。且通过CA724、CA199、CA242、CEA单项及联合检测分析不同分化程度和不同分级的检测情况。结果观察组患者血清肿瘤标志物各项指标明显高于对照1组和对照2组(P0.05和P0.01);且对照1组各项指标均明显高于对照2组(P0.05)。高、中分化组胃癌患者CA724、CA199、CA242阳性率均优于低分化组(P0.05)。各组CEA阳性率差异不明显(P0.05)。Ⅰ和Ⅱ期胃癌患者4种肿瘤标志物阳性水平明显低于Ⅳ期(P0.05)。Ⅰ和Ⅱ期胃癌患者肿瘤标志物阳性率明显高于Ⅳ期(P0.05)。结论肿瘤标志物CA724、CA199、CA242、CEA的水平异常升高或可提示有癌前病变或胃癌的发生,它可作为胃癌早期诊断的重要辅助指标。
[Abstract]:Objective to observe the value of CA724 + CA1999 CA242CEA in the diagnosis of gastric cancer in the elderly. Methods 50 cases of senile gastric cancer were selected as observation group and 50 cases of chronic atrophic gastritis with severe atypical hyperplasia as control group 1. 50 patients with superficial gastritis or normal gastric mucosa were selected as control group. The serum samples of three groups were detected. Fasting venous blood was collected from 10 ml in the morning, separated by centrifuge, and then stored in a frozen refrigerator at -90 鈩，

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