食管切除术后不同吻合方式术后抗反流效果的Meta分析

发布时间：2018-02-12 13:19

本文关键词： 胃底折叠食管癌反流 Meta分析　出处：《兰州大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:采用循证医学的方法系统评价食管切除术吻合口行常规吻合与附加胃底折叠术吻合术后的抗反流效果。方法:通过计算机检索PubMed、EMBASE、Web of Knowledge、The Cochrane Library、中国生物医学文献数据库、万方数据、中国知网和维普数据库,查找关于吻合口常规吻合与附加胃底折叠术两种吻合方式对食管切除术后抗返流效果的研究,检索时限均从建库至2015年1月。资料的提取、质量的评价是通过两个实验人员单独完成的,采用的标准是Cochrane系统评价的方法,然后对数据的Meta分析通过RevMan 5.3软件来完成。结果:共纳入11个RCT试验,1391例患者。Meta分析结果显示:与常规吻合相比,附加胃底折叠术术后能明显降低吻合口反流发生率(OR=0.18,95%CI:0.09~0.33,P0.00001)并不会增加术后吻合口狭窄率(OR=0.53,95%CI:0.28~0.99,P=0.05)。结论:本Meta分析结果显示:食管切除术后吻合口附加胃底折叠术能明显减少吻合口反流情况的发生。
[Abstract]:Objective: to evaluate the anti-reflux effect of esophagectomy anastomosis with routine anastomosis and additional fundus fold anastomosis with evidence-based medicine. Methods: a computer-based search was made for the Cochrane Library of PubMedus EMBASE of knowledge, and the Chinese Biomedical Literature Database was used to evaluate the efficacy of Evidence-based Medicine (EBM) in the treatment of esophagectomy. Wanfang data, China knowledge Network and Weip Database, to find out about the anastomotic anastomosis and the additional stomach fundus anastomosis two kinds of anastomosis to the esophagectomy anti-reflux effect research, the retrieval time is from the establishment of the database to January 2015. The quality evaluation is done by two experimenters alone, and the standard used is the method of Cochrane system evaluation. Then the Meta analysis of the data was performed by RevMan 5.3 software. Results: a total of 1391 patients were included in 11 RCT trials. The incidence of anastomotic regurgitation was significantly decreased after additional fundus folding. Conclusion: the results of Meta analysis showed that anastomotic anastomotic plus fundus folding after esophagectomy could significantly decrease the rate of anastomotic stricture. Conclusion: after esophagectomy, anastomotic plus fundus folding can significantly reduce the rate of anastomotic stricture (P 0.00001). Conclusion: after esophagectomy, anastomotic anastomosis plus fundus folding can significantly reduce the rate of anastomotic stenosis after esophagectomy. Conclusion: after esophagectomy, the rate of anastomosis plus fundus folding can be significantly reduced. The occurrence of anastomotic regurgitation.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R735.1

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