鼻咽癌组织中核磷蛋白表达水平与患者疗效的关系

发布时间：2018-02-13 01:17

本文关键词： 核磷蛋白鼻咽癌免疫组织化学疗效评价　出处：《中国肿瘤生物治疗杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的:探讨核磷蛋白(nucleophosmin,NPM、B23、NO38或NPM1)在鼻咽癌活检组织中的表达水平与增殖指数和患者个体化治疗后疗效的关系。方法:随机选取中山大学肿瘤防治中心2001年1月1日至2003年12月31日期间收治的157例初诊鼻咽癌患者的治疗前活检蜡块,用免疫组织化学法检测鼻咽癌活检组织中NPM1和Ki67的表达,并结合相应临床病理资料,应用统计学方法对结果进行分析。结果:NPM1的表达水平与Ki67的表达水平呈正相关(r=0.445,P0.01),与淋巴结分期呈负相关(N0,N1,N2和N3;r=-0.235,P0.01),但与原发灶分期(T1,T2,T3和T4;r=0.006,P0.05)和临床分期(r=-0.74,P0.05)无相关性。NPM1表达水平与有淋巴结转移组治疗后淋巴结情况呈负相关(r=-0.196,P0.05),与无淋巴结转移组治疗后原发灶情况呈负相关(r=-0.349,P0.05)。NPM1表达水平与预后无明显相关性。结论:NPM1在鼻咽癌组织中高表达并与Ki67的表达水平呈正相关,NPM1有促进细胞增殖的作用且可能作为一个评估个体化治疗疗效的评价指标。
[Abstract]:Objective: to investigate the relationship between the expression level of nucleophosminated nucleophosminn (NPMN) B23NO38 or NPM1) in nasopharyngeal carcinoma biopsy tissues and the proliferative index (Pi) and the curative effect after individualized treatment. Methods: from January 1st 2001 to January 1st 2001, the Cancer Prevention and treatment Center of Sun Yat-sen University was randomly selected. In December 31st 2003, 157 newly diagnosed nasopharyngeal carcinoma patients were treated with paraffin biopsy before treatment. Immunohistochemical method was used to detect the expression of NPM1 and Ki67 in nasopharyngeal carcinoma biopsy tissues. The results were analyzed by statistical method. Results the expression level of Ki67 was positively correlated with the expression level of Ki67, and negatively correlated with lymph node staging, but had no correlation with the primary staging of T1T2T3 and T4R0. 006P0.05) and clinical stage (r-0.74P0.05), but was negatively correlated with lymph node staging (N0. 0N1N 1, N 3, P 1, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05). There was a negative correlation between the level of reach and lymph node status after treatment in the group with lymph node metastasis and the primary tumor after treatment in the group without lymph node metastasis. There was no significant correlation between the expression level of r-0.349P0.05, NPM1 and the prognosis of nasopharyngeal carcinoma. Conclusion the expression level of NPM1 in nasopharyngeal carcinoma is higher than that in the group without lymph node metastasis. The expression of NPM1 was positively correlated with the expression level of Ki67. NPM1 could promote cell proliferation and might be used as an index to evaluate the efficacy of individualized therapy.
【作者单位】：广州医科大学附属第二医院病理科;中山大学肿瘤防治中心分子诊断科;中山大学肿瘤防治中心病理科;
【分类号】：R739.63

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