乳腺包被性乳头状癌的临床病理特征及生存分析

发布时间：2018-02-14 08:24

  本文关键词： 乳腺癌 包被性乳头状癌 临床 生存　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:分析乳腺包被性乳头状癌(encapsulated papillary carcinoma,EPC)的临床、病理特征及生存情况。方法:回顾性分析新疆医科大学附属肿瘤医院2010年1月至2016年12月新疆医科大学附属肿瘤医院收治的63例包被性乳头状癌患者的临床资料,结合文献分析患者的一般情况、临床表现、病理特征、影像学表现、治疗及预后。对比分析单纯性EPC和EPC伴其他类型癌患者临床、病理特征的区别。结果:63例EPC患者均为女性,发病年龄29-82岁,平均年龄60.3岁。影像学检查无特征性表现。免疫组化中ER和PR阳性率分别为90.5%和85.7%,HER-2阳性率为4.8%。单纯性EPC和EPC伴其他类型癌患者的月经状态、ER、PR、Ki67表达、是否发生腋窝淋巴结转移以及分子分型差异有统计学意义(P≤0.05),而两组患者的民族、年龄、肿瘤大小、HER2基因表达以及TNM分期差异无统计学意义(P0.05)。63例EPC患者的1年、2年、5年的无病生存率分别为98.1%、95.7%、80.9%。单纯性EPC患者与EPC伴其他类型癌两组患者的5年无病生存率分别为87.5%与71.5%,两组患者的生存率比较差异有统计学差异(χ2=4.081,P=0.043)。结论:包被性乳头状癌好发于老年女性患者,预后较好,5年无病生存率为80.9%。单纯性EPC预后较EPC伴其他类型癌预后好。单纯性EPC与EPC伴其他类型癌比较患者的月经状态、ER、PR、Ki67表达以及是否发生腋窝淋巴结转移有差异。关于EPC的治疗方式以及预后特点仍需长时间大样本的随访观察。
[Abstract]:Objective: to analyze the clinical features of papillary carcinoma of the breast (EPC). Methods: the clinical data of 63 patients with wrapped papillary carcinoma admitted from January 2010 to December 2016 in the Cancer Hospital affiliated to Xinjiang Medical University were retrospectively analyzed. Combined with literature analysis, the general situation, clinical manifestations, pathological features, imaging manifestations, treatment and prognosis of patients with simple EPC and EPC with other types of cancer were compared and analyzed. Results 63 cases of EPC were all female. The age of onset was 29-82 years with an average age of 60.3 years. The positive rates of ER and PR in immunohistochemical staining were 90.5% and 85.7%, respectively. The positive rates of ER and PR in patients with simple EPC and EPC accompanied with other types of carcinoma were 4.8%. There were significant differences in axillary lymph node metastasis and molecular typing between the two groups (P 鈮，

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