化疗后CIK细胞序贯治疗5例老年急性髓系白血病患者疗效评价

发布时间：2018-02-15 08:09

本文关键词： 细胞因子诱导的杀伤细胞急性髓细胞白血病老年疗效　出处：《安徽医科大学学报》2017年03期 　论文类型：期刊论文

【摘要】：目的初步观察及评价化疗后细胞因子诱导的杀伤细胞(CIK)序贯治疗老年急性髓系白血病(AML)患者的临床疗效,为老年AML患者建立新的副作用较小的维持治疗方法。方法以5例多疗程化疗后疾病达缓解或部分缓解后难以继续耐受化疗的老年AML患者为研究对象,辅以自体CIK细胞序贯治疗。观察分析5例患者CIK细胞输注后一般症状及不良反应,细胞免疫功能状态、外周血微小残留病变(MRD)水平、生活质量评分(KPS)及生存期。结果 5例患者共接受35次CIK细胞回输过程中均未出现不良反应,回输后患者精神、食欲、体力等较前改善。CIK细胞治疗后调节T细胞与效应T细胞比例(2.70±1.59)较CIK细胞输注前(5.35±5.50)明显降低(P0.05)。CIK细胞治疗后患者外周血MRD[(0.16±0.30)%]较CIK细胞治疗前MRD[(0.86±0.84)%]明显降低(P0.05)。CIK细胞输注后患者KPS评分(88.8±6.03)较输注前(75.45±10.35)改善(P0.05),平均总生存期29.8个月。结论本研究5例老年AML患者化疗后自体CIK细胞序贯维持治疗安全有效。
[Abstract]:Objective to observe and evaluate the clinical effect of cytokine-induced cytokine-induced cytokine-induced cytotoxicity (CIK) in elderly patients with acute myeloid leukemia (AML). To establish a new maintenance therapy for elderly patients with AML with less side effects. Methods five elderly patients with AML who had achieved remission or had difficulty in tolerating chemotherapy after more than one course of chemotherapy were studied. The general symptoms and adverse reactions, cellular immune function, and the level of minimal residual lesions in peripheral blood were observed and analyzed in 5 patients after CIK cell infusion, followed by sequential treatment with autologous CIK cells. Results there was no adverse reaction during 35 times of CIK cell transfusion in 5 patients. The ratio of regulating T cells to effector T cells (2.70 卤1.59) was significantly lower than that of CIK cells (5.35 卤5.50) after treatment. The level of MRD in peripheral blood of patients with CIK cells after treatment [0.16 卤0.30%] was significantly lower than that of CIK cells [0.86 卤0.84%]. The KPS score (88.8 卤6.03) was better than that before infusion (75.45 卤10.35). The average survival time was 29.8months. Conclusion Sequential maintenance of autologous CIK cells in 5 elderly patients with AML after chemotherapy is safe and effective.
【作者单位】：安徽医科大学第二附属医院血液科生物医疗研究中心安徽医科大学血液病研究中心;
【基金】：国家自然科学基金(编号:81401293) 安徽高校省级自然科学研究重大项目(编号:KJ2014ZD17)
【分类号】：R733.71

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