饮茶与牙龈癌发病关系的病例对照研究

发布时间：2018-02-15 23:38

本文关键词： 牙龈癌饮茶病例对照研究　出处：《肿瘤防治研究》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨饮茶对牙龈癌发病的影响。方法采用病例对照的研究方法,病例组为2 0 1 0年1 2月—2 0 1 6年3月经病理确诊的牙龈癌新发病例1 2 1例,同期经性别、年龄成组匹配,选取医院体检人群及社区健康人群363例作对照。应用非条件Logistic回归模型计算饮茶及其相关变量与牙龈癌发病风险的调整比值比(OR)及其95%置信区间(CI)并进行相乘交互作用分析。结果饮茶可降低牙龈癌的发病风险(OR=0.51,95%CI:0.29~0.90);进一步分析发现随着每日饮茶量的增加、饮茶年限的延长,牙龈癌的发病风险也随之降低(均Ptrend0.05);此外饮茶年龄≥25岁、饮茶浓度适中、饮温茶以及饮绿茶和乌龙茶也可降低牙龈癌的发病风险。分层分析结果发现与吸烟者相比,在非吸烟者中饮茶的保护作用更加显著(OR=0.40,95%CI:0.1 7~0.9 6),在非饮酒和饮酒者中饮茶的保护作用差异则没有统计学意义。交互作用结果并未发现吸烟与饮茶,饮酒与饮茶之间存在相乘交互作用。结论饮茶是牙龈癌发病的保护因素,且每日饮茶量、饮茶年限与牙龈癌发病风险之间呈剂量反应关系。
[Abstract]:Objective to investigate the effect of tea drinking on the incidence of gingival cancer. Methods A case-control study was conducted. The case group consisted of 121 new cases of gingival cancer confirmed pathologically from December to March 2006, with sex at the same time. Age matched in groups, Three hundred and thirty-three healthy people in hospitals and in the community were selected as controls. The adjusted ratio of tea drinking and its related variables to the risk of gingival cancer was calculated by using the non-conditional Logistic regression model and the 95% confidence interval (CI) was calculated and multiplied. Results Tea drinking decreased the risk of gingival cancer. The risk of gingival cancer was decreased with the prolongation of tea drinking time (all P trend 0.05), and the age of tea drinking was more than 25 years, and the tea concentration was moderate. Drinking warm tea, green tea and oolong tea also reduced the risk of gingival cancer. The protective effect of tea drinking in non-smokers was more significant than that in non-smokers. The protective effect of drinking tea in non-smokers was significantly higher than that in non-smokers, but there was no significant difference in the protective effects of drinking tea between non-drinkers and non-drinkers. Conclusion Tea drinking is the protective factor of gingival cancer, and there is a dose-response relationship between the amount of tea consumed daily, the length of tea drinking and the risk of gingival cancer.
【作者单位】：福建医科大学公共卫生学院流行病与卫生统计学系;福建医科大学公共卫生学院环境因素与肿瘤福建省重点实验室;福建医科大学附属第一医院口腔颌面外科;
【基金】：中央财政支持地方高校发展专项资金环境与健康表观遗传学研究创新团队项目(1003-03900130) 福建省教育厅资助省属高校项目(JK2015017) 福建省科技厅科研项目(2015J01304)
【分类号】：R739.8

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