卵巢浆液性腺癌中SP1、KLF4和p21表达及其预后意义

发布时间：2018-02-17 03:30

本文关键词： 卵巢肿瘤浆液性腺癌 SP KLF p 预后　出处：《临床与实验病理学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨不同级别卵巢浆液性腺癌中SP1、KLF4和p21蛋白表达的差异和预后意义。方法应用免疫组化EliVision法检测卵巢低级别和高级别浆液性腺癌中SP1、KLF4和p21蛋白的表达,Kaplan-Meier单因素和Cox多因素生存分析其与患者预后的关系。结果 SP1、KLF4和p21蛋白在高级别浆液性腺癌中的阳性率分别为74.5%、17.0%和11.7%,低级别浆液性腺癌中的阳性率分别为65.2%、34.8%和26.1%,与对照组相比,SP1表达均明显升高(P0.05),而KLF4和p21表达均明显降低(P0.05)。三者在高、低级别液性腺癌中的表达差异无显著性(P0.05)。SP1、KLF4和p21蛋白表达与高级别液性腺癌FIGO分期密切相关,且SP1还与术后有无残留灶密切相关(P0.05)。卵巢高级别液性腺癌中SP1表达与KLF4、p21的表达均呈显著负相关(P0.05)。高级别液性腺癌中SP1蛋白阳性者的5年生存率明显低于阴性者,而KLF4和p21蛋白阳性者的5年生存率明显高于阴性者(P0.05)。Cox多因素分析显示,FIGO分期和SP1高表达是影响高级别浆液性腺癌预后的独立因素。结论 SP1蛋白过表达以及KLF4和p21蛋白低表达,参与了高、低级别浆液性腺癌的发生,三者表达与高级别浆液性腺癌的预后有关,且SP1是独立预后因素。
[Abstract]:Objective to investigate the difference of SP1KLF4 and p21 protein expression and their prognostic significance in ovarian serous adenocarcinoma with different grades. Methods Immunohistochemical EliVision method was used to detect the expression of SP1mKLF4 and p21 protein in ovarian low-grade and high-grade serous adenocarcinoma. Results the positive rates of SP1mKLF4 and p21 protein in high grade serous adenocarcinoma were 74.50% and 11.70.The positive rates of SP1mKLF4 and p21 protein in low-grade serous adenocarcinoma were 34.8% and 26.1%, respectively. Compared with the control group, the expression of SP1 increased significantly, while the expression of KLF4 and p21 decreased significantly. The expression of KLF4 and p21 protein in low grade liquid adenocarcinoma was not significantly correlated with the FIGO stage of high grade liquid adenocarcinoma. The expression of SP1 was negatively correlated with the expression of KLF4 p21. The 5-year survival rate of the patients with positive SP1 protein was significantly lower than that of the negative ones. The 5-year survival rate of patients with positive KLF4 and p21 protein was significantly higher than that of patients with negative P0.05. Cox multivariate analysis showed that Figo stage and high expression of SP1 were independent factors influencing prognosis of high grade serous adenocarcinoma. Conclusion the overexpression of SP1 protein and the low expression of KLF4 and p21 protein are independent factors for prognosis of high grade serous adenocarcinoma. The expression of these three proteins was related to the prognosis of high grade serous adenocarcinoma and SP1 was an independent prognostic factor.
【作者单位】：河北医科大学第四医院妇科;河北医科大学第二医院病理科;
【基金】：河北省科技支撑计划(16277794D)
【分类号】：R737.31

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