腹腔镜单侧肾上腺全切术与部分切除术治疗肾上腺醛固酮瘤有效性和安全性的Meta分析

发布时间：2018-02-19 21:29

本文关键词： 肾上腺醛固酮瘤腹腔镜肾上腺部分切除术腹腔镜肾上腺全切除术 Meta分析偏倚　出处：《河北医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:比较腹腔镜肾上腺全切术(laparoscopic total adrenalectomy,LA)与部分切除术(laparoscopic partial adrenalectomy,LPA)治疗肾上腺醛固酮瘤(aldosterone-producing adenomas,APA)的疗效。方法:应用计算机检索1988-01至2014-05期间Pubmed,Dspace,Social Science Research Network,CNKI,万方数据库。纳入涉及腹腔镜单侧肾上腺全切术与部分切除术治疗肾上腺醛固酮瘤有效性及安全性的研究。依据Cochrane手册对所有纳入研究进行质量评价并应用Stata11软件进行Meta分析。结果:共纳入7个研究,包括914例患者,腹腔镜单侧肾上腺部分切除术组共511例,腹腔镜单侧肾上腺全切术组共403例。所有7篇研究进行Meta分析,结果显示LPA组与LA组手术时间差异无统计学意义[WMD=2.436,95%CI(-4.834,9.706),P0.05];LPA组与LA组出血量差异无统计学意义[WMD=3.225,95%CI(-5.654,12.103),P0.05];LPA组与LA组手术后引流管拔除时间差异无统计学意义[Z=0.40,95%CI(-0.299,0.198),P0.05];LPA组与LA组住院天数差异无统计学意义[Z=0.33,95%CI(-0.325,0.230),P0.05]。结论:针对肾上腺醛固酮瘤的手术治疗,腹腔镜肾上腺全切术与部分切除术在手术时间、术中出血量、术后伤口引流管拔除时间、住院时间上的差异均无统计学意义。上述结论尚需高质量、大样本的随机对照试验加以证实。
[Abstract]:Objective: to compare the efficacy of laparoscopic total adrenalectomy with partial partial in the treatment of adrenal aldosterone-producing adenomatosis (APA). Methods: a computer-based search of PubmedDspacespace Social Science Research Network CNKI was performed from January 1988 to May 2014-05, which was included in the database of adrenal aldosterone-producing adrenal aldosterone. Study on the efficacy and safety of laparoscopic unilateral total adrenalectomy and partial resection in the treatment of adrenal aldosteronoma. All included studies were evaluated according to the Cochrane manual and Meta analysis was performed using Stata11 software. A total of seven studies were included, There were 511 cases in laparoscopic partial adrenalectomy group and 403 cases in laparoscopic total adrenalectomy group. All 7 studies were analyzed by Meta. The results showed that there was no significant difference in the operation time between LPA group and LA group [WMD-4.834-9.706] there was no significant difference in the bleeding volume between LPA group and LA group [WMD3.225 95CIM-5.654 + 12.103] there was no significant difference between LPA group and LA group in the extubation time after operation. There was no significant difference in the difference between the two groups. Conclusion: the surgical treatment of adrenal aldosteronoma was performed on adrenal aldosterone tumor. There was no significant difference between total laparoscopic adrenalectomy and partial adrenalectomy in operative time, blood loss during operation, extubation time of wound drainage tube after operation and hospitalization time. Large samples of randomized controlled trials were confirmed.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R736.6

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