HERC2在乳腺癌中的表达及其与病理参数关系的初步研究

发布时间：2018-02-20 23:29

本文关键词： HERC 乳腺癌免疫组化蛋白印迹　出处：《广东医学》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨HERC2在不同乳腺癌组织中的表达及其在浸润性导管癌中表达与病理参数之间的关系。方法用免疫组化检测HERC2在正常乳腺组织、乳腺良性病变、导管原位癌和浸润性导管癌中的表达;用Western blot检测HERC2在正常乳腺组织和浸润性导管癌组织中的表达。结果 (1)免疫组化显示HERC2在乳腺良性病变、导管原位癌、浸润性导管癌中阳性率分别为8%(4/50)、32%(16/50)、58%(29/50),其组间差异均有统计学意义(P0.01),HERC2在正常乳腺组织中阳性率为4%(2/50)。(2)HERC2在浸润性导管癌中的表达与腋窝淋巴结转移、组织学分级相关(P0.05)。(3)Western blot显示HERC2在浸润性导管癌组织中的表达高于其在正常乳腺组织中的表达,差异有统计学意义(P0.05)。结论 HECR2可能与乳腺癌的发生、发展、预后评估相关。
[Abstract]:Objective to investigate the expression of HERC2 in breast cancer tissues and its expression in invasive ductal carcinoma and pathological parameters between. Immunohistochemical method was used to detect HERC2 in normal breast tissue, breast benign lesions, the expression of ductal carcinoma in situ and invasive ductal carcinoma; expression of Western blot HERC2 was detected in normal breast tissue and invasive ductal carcinoma. Results (1) immunohistochemistry showed HERC2 in breast benign lesions, ductal carcinoma in situ and invasive ductal carcinoma, the positive rate was 8% (4/50), 32% (16/50), 58% (29/50), the differences between groups were statistically significant (P0.01), HERC2 in normal breast tissue, the positive rate was 4% (2/50). (2) HERC2 in invasive ductal carcinoma and the expression of axillary lymph node metastasis, histological grading (P0.05). (3) Western blot showed that the expression of HERC2 in invasive ductal carcinoma than in normal breast The expression in the tissue was statistically significant (P0.05). Conclusion HECR2 may be related to the occurrence, development and prognosis of breast cancer.

【作者单位】：南昌大学第二附属医院病理科;河南省肿瘤医院病理科;江西省肿瘤医院病理科;九江市第三人民医院病理科;
【基金】：国家自然科学基金资助项目(编号:30960430) 南昌大学研究生创新专项资金项目(编号:cx2015151)
【分类号】：R737.9

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