CAR-T的设计原理及其在卵巢癌治疗中的应用挑战

发布时间：2018-02-25 20:20

  本文关键词： 嵌合型抗原受体T细胞 卵巢癌　出处：《免疫学杂志》2017年02期 　论文类型：期刊论文

【摘要】：嵌合型抗原受体T细胞(CAR-T)是通过基因工程方法表达特定靶抗原抗体单链可变区(sc Fv)的T细胞。随着CAR-T在血液系统肿瘤治疗疗效的确定,实体肿瘤的研究者们也开始试用CAR-T治疗。然而,CAR-T在实体肿瘤中的治疗疗效远远低于预期。本文对CAR-T的设计原理做了简单的总结并讨论各种形式CAR-T及其优缺点。在此基础上,我们也讨论了CAR-T在实体肿瘤中疗效低的原因。最后,我们以卵巢癌为例对CAR-T研究存在的挑战做了前瞻性的预测。
[Abstract]:Chimeric antigen receptor T cells (CAR-T) are T cells expressing single chain variable region (sc FV) of specific target antigen antibodies by genetic engineering. The researchers of solid tumor have also begun to try CAR-T treatment. However, the therapeutic effect of CAR-T in solid tumor is much lower than expected. This paper briefly summarizes the design principle of CAR-T and discusses the various forms of CAR-T and its advantages and disadvantages. We also discussed the reasons for the low efficacy of CAR-T in solid tumors. Finally, we used ovarian cancer as an example to predict the challenges of CAR-T research.
【作者单位】： 同济大学附属第十人民医院妇产科;
【分类号】：R737.31
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