肺浸润性腺癌能谱CT碘基物质分析与Ki-67表达的相关性研究

发布时间：2018-02-27 15:19

本文关键词： 肺浸润性腺癌能谱CT Ki-　出处：《临床放射学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨肺浸润性腺癌的能谱CT碘基物质分析与Ki-67表达程度的相关性。方法回顾性分析经病理证实的44例肺浸润性腺癌患者资料,所有患者的免疫组织化学指标均包括Ki-67,并且于术前行能谱CT增强扫描,包括动脉期及静脉期,分别延迟25 s、55 s。根据CT纵隔窗上肿瘤含实性成分的多少,分成实性结节组(18例)、m GGN组(19例)、p GGN组(7例)。采用Spearman相关法分析所有病例中Ki-67与动脉期及静脉期肿瘤平均碘基值的相关性,及与肿瘤实性成分多少的相关性;分别分析实性结节组、m GGN组、p GGN组中Ki-67与动脉期及静脉期肿瘤平均碘基值的相关性。结果所有病例中,Ki-67与动脉期及静脉期肿瘤平均碘基值均呈负相关性(P0.05)。另外,Ki-67与肺癌结节中实性成分呈正相关(P=0.02,r=0.36)。实性结节组和m GGN组中,Ki-67与动脉期及静脉期肿瘤平均碘基值均呈负相关性(P0.05)。p GGN组中,Ki-67与动脉期及静脉期肿瘤平均碘基值均无相关性(P0.05)。Ki-67分组中动脉期及静脉期平均碘基值均有明显差异性(P0.05)。结论肺浸润性腺癌的碘基值与Ki-67具有较好的负相关性,在评估肿瘤增殖能力上可以对Ki-67进行补充。
[Abstract]:Objective to investigate the correlation between the expression of Ki-67 and the level of Ki-67 expression in invasive lung adenocarcinoma. Methods 44 cases of lung invasive adenocarcinoma confirmed by pathology were retrospectively analyzed. Ki-67 was included in all patients, and enhanced EDS CT scan was performed before operation, including arterial phase and venous phase, with a delay of 25 s or 55 s. According to the solid composition of the tumor in the mediastinal window of CT, A total of 18 cases of solid nodules were divided into two groups: GGN group (n = 19) and GGN group (n = 7). Spearman correlation method was used to analyze the correlation between Ki-67 and the mean iodine base value of arterial and venous tumors, and the correlation between Ki-67 and tumor solid composition. The correlation between Ki-67 and the mean iodine base value of arterial and venous phase tumors in solid GGN group was analyzed respectively. Results in all cases, Ki-67 was negatively correlated with the mean iodine base value in arterial phase and venous phase. In addition, Ki-67 had a negative correlation with the mean iodine base value in arterial phase and venous phase. There was a positive correlation between Ki-67 and the mean iodine base value in arterial and venous phase in solid nodule group and m GGN group. There was no significant difference between Ki-67 value and average iodine base value in arterial phase and venous phase in P0.05 + p GGN group. There were significant differences in the average iodine base values in arterial and venous phases in P0.05. Ki-67 groups. Conclusion there is a good negative correlation between iodine base value and Ki-67 in pulmonary infiltrating adenocarcinoma. Ki-67 may be supplemented in evaluating tumor proliferation.
【作者单位】：大连医科大学附属第一医院放射科;
【分类号】：R734.2;R730.44

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