腹腔镜辅助对比开腹手术治疗胃肠道间质瘤的meta分析

发布时间：2018-02-27 17:47

本文关键词： 胃肠道间质瘤腹腔镜手术开腹手术 Meta分析　出处：《南昌大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的本Meta分析从询证医学的角度运用数据分析的方法对胃肠道间质瘤的手术方式进行对比,评价在腹腔镜辅助下行胃肠道间质瘤切除术(LAP)和开腹手术(OPEN)在胃肠道间质瘤治疗中的安全性、有效性、微创性。方法通过南昌大学图书馆计算机检索Pubmed、Elsevier、SPRINGER、The Cochrane Library等数据库。收集2004年1月至2014年3月发表的有关腹腔镜辅助胃肠道间质瘤切除术(LAP)和开腹胃肠道间质瘤切除术(OPEN)对比的英文文献,先按照纳入和排除的标准筛选文献、然后提取资料并对文献进行质量评价,最后利用Review Manager 5.2软件进行Meta分析。结果本Meta分析共纳入12篇文献(共有719例病人),其中LAP组345例,OPEN组374例。荟萃分析结果显示,与OPEN相比,LAP在术后排气时间、进流质时间和住院时间方面更短(P=0.04、P0.00001、P0.00001),在术后并发症发生率及复发率方面更低(P=0.0004、0.005),而在手术时间、术中出血量方面二者差异无统计学意义(P0.05)。结论LAP与OPEN对比在加快术后恢复、减少并发症、降低复发率上体现了明显的微创优势。所以LAP在技术上是可行的,具有良好的安全性,并能获得良好的近期疗效。
[Abstract]:Objective to compare the surgical methods of gastrointestinal stromal tumors (GIST) by using the data analysis method from the point of view of inquiry medicine. To evaluate the safety and efficacy of laparoscopic assisted resection of gastrointestinal stromal tumors (LAP) and open surgery (OPEN) in the treatment of gastrointestinal stromal tumors (GIST). Methods the database of Pubmedus Elsevier SPRINGERN, the Cochrane Library, etc., published from January 2004 to March 2014, was collected from the Library of Nanchang University for laparoscopic assisted gastrointestinal stromal tumor resection (LAP) and open gastrointestinal stromal tumor resection (GIST). OPEN) A comparative English literature, The literature is screened according to the criteria for inclusion and exclusion, and then the data is extracted and the quality of the literature is evaluated. Finally, Meta analysis was carried out with Review Manager 5.2 software. Results the Meta analysis included 12 articles (719 patients), including 345 patients in LAP group and 374 patients in open group. The results of meta-analysis showed that compared with OPEN, lap had postoperative exhaust time. The time of entering fluid and the time of hospitalization were shorter than that of P0. 04 and P0. 001 + P0. 0001, and the incidence and recurrence rate of postoperative complications were lower than that of P0. 0004 + 0. 005, but there was no significant difference between them in the time of operation and the amount of blood loss during operation. Conclusion compared with OPEN, LAP and OPEN can accelerate the postoperative recovery. Therefore, LAP is technically feasible, has good safety, and can obtain good short-term curative effect.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R735

【参考文献】