腹腔镜与开腹根治术术后直肠癌患者感染率及对炎症因子的影响

发布时间：2018-02-28 22:16

本文关键词： 腹腔镜直肠癌感染炎症因子　出处：《中华医院感染学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的比较腹腔镜与开腹根治术术后直肠癌患者感染率及对炎症因子的影响,为临床治疗提供依据。方法选取2012年8月-2015年8月医院收治的直肠癌患者138例,根据治疗时间不同将其分为腹腔镜组76例与开腹组62例;腹腔镜组采用腹腔镜直肠癌根治术治疗,开腹组采用开腹直肠癌根治术治疗,术后观察两组患者感染发生情况,并对两组治疗前后炎症因子变化进行比较。结果腹腔镜组术后感染率为2.62%,开腹组术后感染率为11.29%,两组间比较差异有统计学意义(P0.05);手术前,腹腔镜组与开腹组血清C-反应蛋白(CRP)、白介素6(IL-6)及肿瘤坏死因子-α(TNF-α)水平相当,比较差异无统计学意义;与开腹组比较,腹腔镜组患者术后1、3、5d血清CRP、IL-6水平明显降低,TNF-α水平明显升高,差异有统计学意义(P0.05)。结论与开腹直肠癌根治术相比,腹腔镜直肠癌根治术术后患者感染率更低,对机体炎症因子的影响更小,且无严重并发症,值得临床推广应用。
[Abstract]:The rate and its influence on inflammatory factors in patients with rectal cancer infection objective to compare laparoscopic and open radical resection, provide the basis for clinical treatment. Methods 138 patients with rectal cancer from August 2012 -2015 year in August admitted to the hospital, according to the different treatment time will be divided into 76 cases of laparoscopic group and laparotomy group 62 cases; the laparoscopic group used laparoscopic radical rectal cancer surgery, laparotomy group with open radical resection of rectal cancer patients after treatment, two groups were observed in patients with infection, and the changes of inflammatory factors in the two groups before and after treatment were compared. Results the laparoscopic group postoperative infection rate was 2.62%, the laparotomy group postoperative infection rate was 11.29%, there was significant difference between the two groups (P0.05); before the surgery, laparoscopic group and laparotomy group serum C- reactive protein (CRP), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF- alpha) level, there was no statistically significant difference compared with laparotomy; Group, the laparoscopic group of patients after 1,3,5d serum CRP, IL-6 levels were significantly decreased, TNF- levels increased significantly, the difference was statistically significant (P0.05). Conclusion compared to radical surgery and open surgery for colorectal cancer, lower rate of infection in patients with rectal cancer after laparoscopic radical resection, less impact on the body inflammatory factor, and without serious complications. It is worthy of clinical application.

【作者单位】：安吉县人民医院普外科;浙江大学附属第一医院胃肠外科;辉瑞(北京)国际医学研究院药物试验中心;
【基金】：浙江省医药卫生科技计划(2012WSR122)
【分类号】：R735.37

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