食管癌患者血清维生素E水平meta分析

发布时间：2018-03-03 05:37

本文选题：食管癌　切入点：血清　出处：《中国公共卫生》2017年04期 　论文类型：期刊论文

【摘要】：目的了解食管癌患者血清维生素E水平,为食管癌的防治及病因探索提供参考依据。方法检索中国知网数据库、万方数据库、Pub Med数据库、Web of Science数据库,并辅以手工检索和文献追溯法收集1980年1月—2015年12月公开发表的关于食管癌患者血清维生素E水平的相关文献;采用Stata 12.0软件对纳入的文献进行meta分析。结果最终纳入9篇文献(中文文献7篇,英文文献2篇),累计病例组患者358例,对照组人群538例;meta分析结果显示,病例组食管癌患者血清维生素E水平较对照组人群低(SMD=-0.50,95%CI=-0.65~-0.36,P0.001);亚组分析结果显示,国家为中国(SMD=-0.50,95%CI=-0.67~-0.33)和其他国家(SMD=-0.51,95%CI=-0.77~-0.25)、对照来源于社区(SMD=-0.54,95%CI=-0.69~-0.39)、样本量50例(SMD=-0.56,95%CI=-0.71~-0.41)、年龄匹配(SMD=-0.57,95%CI=-0.72~-0.42)、测定方法为高效液相色谱法(SMD=-0.41,95%CI=-0.59~-0.24)和其他方法(SMD=-0.67,95%CI=-0.91~-0.43)的研究中病例组食管癌患者血清维生素E水平均低于对照组人群(均P0.001);敏感性分析和发表偏倚检验结果显示,本研究meta分析结果稳定,且不存在发表偏倚。结论食管癌患者血清维生素E水平较低。
[Abstract]:Objective to investigate the serum vitamin E level in patients with esophageal cancer and to provide reference for the prevention and treatment of esophageal cancer and to explore the etiology of esophageal cancer. The related literatures on serum vitamin E levels of esophageal cancer patients published from January 1980 to December 2015 were collected by manual retrieval and literature tracing. Stata 12.0 software was used to analyze the included literature by meta. Results 9 articles (7 in Chinese and 2 in English) were included. There were 358 cases in the cumulative case group and 538 cases in the control group. The serum vitamin E levels of esophageal cancer patients in the case group were lower than those in the control group. The country is SMD-0.5095CI-0.67CI-0.33) and other countries (SMD-0.5195CI-0.77CI-0.25). The control group comes from community SMD-0.5495CI-0.69CI-0.399.A sample of 50 cases of SMD-0.5695CI-0.71-0.41, age-matched SMD-0.595CI-0.72-0.42J is determined by high performance liquid chromatography (HPLC) with SMD-0.419 CI-0.24) and other methods. The results of sensitivity analysis and publication bias test showed that, The results of meta analysis were stable, and there was no publication bias. Conclusion the serum vitamin E level of esophageal cancer patients is lower.
【作者单位】：郑州大学公共卫生学院营养与食品卫生学教研室;新乡医学院基础医学院;
【基金】：国家自然科学基金(81402670)
【分类号】：R735.1

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