肺癌细胞及其聚苯乙烯微球模型的光散射研究（英文）

发布时间：2018-03-06 08:58

本文选题：光散射　切入点：数值仿真　出处：《红外与激光工程》2017年10期 　论文类型：期刊论文

【摘要】：在生物医学和临床医学领域,许多疾病的诊断和治疗依赖于细胞形态的识别。不同细胞具有不同的形态,这些形态的不同将导致生物组织中光传播特征的变化,更重要的是这将影响细胞的光散射特性。目前,动态光散射理论是动态识别细胞尺寸和形状的最佳方式。细胞主要由细胞质、细胞核和线粒体组成,因此,分析它们的光散射特性对于光学诊断和治疗具有非常重要的意义。设计实验获取了癌细胞和聚苯乙烯球的光散射特性,并利用时域有限差分法建立细胞质模型进行细胞光散射特性仿真。从肺癌细胞的光散射结果可以看出,线粒体对前向散射(0°~20°)和后向散射(160°~180°)贡献最大,细胞核对侧向散射(80°~100°)贡献最大,细胞质对各个角度贡献均等。仿真结果和实验结果基本一致。
[Abstract]:In biomedical and clinical medicine, the diagnosis and treatment of many diseases depend on the recognition of cell morphology. More importantly, this will affect the light scattering properties of cells. At present, dynamic light scattering theory is the best way to dynamically recognize the size and shape of cells. Cells are mainly composed of cytoplasm, nucleus and mitochondria, so, Analysis of their light scattering properties is of great significance for optical diagnosis and treatment. The light scattering properties of cancer cells and polystyrene spheres are obtained by designing experiments. The cytoplasmic model of lung cancer cells was established by using finite-difference time-domain (FDTD) method to simulate the light scattering characteristics of the cells. It can be seen from the light scattering results of lung cancer cells that mitochondria contribute the most to the forward scattering (0 掳~ 20 掳) and the backward scattering (160 掳~ 180 掳). The contribution of nucleus to lateral scattering was the largest and the contribution of cytoplasm to each angle was equal. The simulation results were consistent with the experimental results.
【作者单位】：重庆大学光电技术及系统教育部重点实验室;
【基金】：国家自然科学基金(61377001)
【分类号】：R73-3

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