番泻叶联合炙甘草泡服缓解肿瘤患者化疗后便秘的疗效及副作用观察

发布时间：2018-03-08 22:05

本文选题：肿瘤　切入点：化疗　出处：《广州中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:在运用番泻叶缓解肿瘤患者化疗后便秘的同时也伴随着诸如腹痛、腹泻等不良反应的产生,本研究通过运用番泻叶联合炙甘草,观察可否在缓解肿瘤患者化疗后便秘的同时减轻番泻叶的副作用。为今后运用番泻叶缓解化疗后便秘提供更多的临床依据。方法:将化疗过程中或化疗结束后出现便秘的60例患者分为实验组和对照组,实验组采用番泻叶10g、炙甘草10g泡服,对照组采用番泻叶10g泡服,观察两者患者便秘的缓解情况及副作用发生情况。成果:实验组当中显效15例,有效10例,无效5例,其中腹泻18例,腹泻率60%,总有效率83.3%;对照组当中显效16例,有效8例,无效6例,其中包含腹泻20例,腹泻率66.7%,总有效率80%,等级资料的比较采用非参数检验,实验组和对照组疗效差异无统计学意义(p0.05);实验组中发生腹痛者5例,呕吐2例,恶心3例,腹胀6例,对照组腹痛12例,呕吐8例,恶心10例,腹胀14例,两组在副作用发生率上差异具有统计学意义(p值0.05)。结论:番泻叶配合炙甘草的有效率与单独使用番泻叶相当,而副作用发生率明显低于单独使用番泻叶,提示番泻叶配合炙甘草在降低副作用的前提下可有效缓解便秘。
[Abstract]:Objective: to alleviate constipation after chemotherapy in patients with tumor by using Senna leaf, accompanied by adverse reactions such as abdominal pain and diarrhea. To observe the possibility of relieving constipation after chemotherapy in cancer patients while alleviating the side effects of Senna leaf. To provide more clinical basis for the application of Senna leaf in relieving constipation after chemotherapy. Methods: to release the Senna leaf during chemotherapy or after chemotherapy. 60 patients with constipation were divided into experimental group and control group. The experimental group was treated with 10 g Senna leaf, the control group with 10 g Senna leaf, and the control group with 10 g of Senna leaf. The remission and side effects of constipation were observed. Results: in the experimental group, 15 cases were effective, 10 cases were effective, and 5 cases were ineffective. Among them, 18 cases had diarrhea, the diarrhea rate was 60%, and the total effective rate was 83.3%. In the control group, 16 cases were effective, 8 cases effective, 6 cases ineffective, including 20 cases of diarrhea, 66.7% of diarrhea rate, 80% of total effective rate, and non-parametric test was used to compare the grade data. There were 5 cases of abdominal pain, 2 cases of vomiting, 3 cases of nausea, 6 cases of abdominal distension, 12 cases of abdominal pain, 8 cases of vomiting, 10 cases of nausea and 14 cases of abdominal distension. Conclusion: the effective rate of Senna leaf combined with baked licorice is the same as that of Senna leaf alone, and the side effect rate is obviously lower than that of Senna leaf alone. The results suggest that Senna combined with Glycyrrhiza uralensis can effectively relieve constipation on the premise of reducing side effects.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R730.53

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