代谢综合征和前列腺癌的相关性研究

发布时间：2018-03-10 16:11

本文选题：代谢综合征　切入点：前列腺癌　出处：《山东大学》2017年硕士论文　论文类型：学位论文

【摘要】：前列腺癌(prostate cancer,PCa)是男性老年人常见疾病。前列腺癌在全球癌症发病率中排第二,病死率中排第六。在欧美发病率极高,目前在美国前列腺癌发病率已经超过肺癌成为第一位危害男性健康的肿瘤。随着我国人均寿命的不断增长,饮食结构的改变及诊疗技术的提高等,近年发病率迅速增加。代谢综合征(metabolic syndrome,MS)是心血管病的多种代谢危险因素(与代谢异常相关的心血管病危险因素)在个体内集结的状态,是人体能量的利用和储存的异常。随着生活水平提高和生活方式改变,我国代谢综合征的发病率也明显升高,现已成为一公共健康问题代谢综合证和前列腺癌之间的关系尚未有结论,已经发表的论文中观点各不相同。根据在斯堪的纳维亚和非洲裔美国人的人群中研究,代谢综合征及其成分能够提高前列腺癌的发病率,但是也有研究者在斯堪的纳维亚和美国白人的研究中得到相反的结论。研究目的:明确代谢综合征和前列腺癌的发病及进展的相关性,以早期预防和治疗前列腺癌。资料和方法:1.伦理声明2.研究对象及排除标准纳入研究对象为汉族人,无恶性肿瘤、肝肾疾病、前列腺癌家族史。长期服用影响血脂、血压或相关代谢指标的药物的患者被排除。3.数据收集记录研究对象的信息包括年龄,身高(cm),体重(kg),体重指数,收缩压及舒张压。记录空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白和高密度脂蛋白。所有前列腺癌患者经病理确认,并记录gleason评分和TNM分期。4.统计分析结果:1.实验组和对照组中代谢综合征和前列腺癌的相关性研究实验组明显比对照组年龄大(P0.001),实验组人群身高体重指数、甘油三酯、总胆固醇和高密度脂蛋白比对照组低。2.对照组,低危前列腺癌组,高危前列腺癌组中代谢综合征和前列腺癌的相关性研究对照组年龄更低,总胆固醇更高。舒张压,甘油三酯和高密度脂蛋白在对照组和高危组间有差异。身高体重指数与前列腺癌发病相关。3.对照组,低危前列腺癌组,高位前列腺癌组中代谢综合征和前列腺癌的logistic回归分析年龄、总胆固醇与高低危前列腺癌相关。结论:年龄、总胆固醇与前列腺癌的发病及确诊的前列腺癌的危险程度相关。舒张压、甘油三酯、高密度脂蛋白与前列腺癌的发病及确诊的前列腺癌的高危相关。身高体重指数与前列腺癌的发病相关。
[Abstract]:Prostate cancer is a common disease among male elderly people. Prostate cancer is the second most common disease in the world, with a mortality rate of 6th. In Europe and the United States, the incidence of prostate cancer is extremely high. At present, the incidence of prostate cancer in the United States has surpassed that of lung cancer as the first cancer that endangers the health of men. With the continuous increase in life expectancy, changes in dietary structure, and the improvement of diagnostic and therapeutic techniques in China, The incidence of metabolic syndrome is increasing rapidly in recent years. Metabolic syndromes (MSS) is the accumulation of many metabolic risk factors (cardiovascular risk factors associated with abnormal metabolism) in individuals. It is the abnormal use and storage of human energy. With the improvement of living standards and lifestyle changes, the incidence of metabolic syndrome in China also increases significantly. The relationship between metabolic syndromes and prostate cancer, which has become a public health problem, has yet to be concluded, and opinions vary in published papers, according to a study in Scandinavia and African-American populations. Metabolic syndrome and its components can increase the incidence of prostate cancer. But researchers in Scandinavia and white America have come to the opposite conclusion. The purpose of the study was to determine the association between metabolic syndrome and prostate cancer. To prevent and treat prostate cancer early. Data and methods: 1. Ethical statement 2.The subjects and exclusion criteria were Han nationality, no malignant tumor, liver and kidney disease, prostate cancer family history. Patients with blood pressure or related metabolic indicators were excluded .3.The data collected to record subjects' information included age, height, body weight, body mass index, systolic and diastolic blood pressure, fasting blood glucose, triglyceride, total cholesterol, Low density lipoprotein and high density lipoprotein. All prostate cancer patients are pathologically confirmed, The correlation between metabolic syndrome and prostate cancer in the experimental group and the control group was studied. The age of the experimental group was significantly older than that of the control group (P 0.001). The body weight index (BMI) and triglyceride (TG) of the experimental group were significantly higher than that of the control group. The correlation between metabolic syndrome and prostate cancer in control group, low risk prostate cancer group, high risk prostate cancer group; the control group was younger, the total cholesterol was higher. Triglyceride and high density lipoprotein were different between control group and high risk group. High body mass index (BMI) was associated with prostate cancer. Control group, low risk prostate cancer group, Logistic regression analysis of metabolic syndrome and prostate cancer in high prostate cancer group, total cholesterol was associated with high and low risk prostate cancer. Total cholesterol is associated with the incidence of prostate cancer and the risk of diagnosed prostate cancer. High density lipoprotein was associated with the incidence of prostate cancer and the high risk of diagnosed prostate cancer. Height and body mass index were associated with the incidence of prostate cancer.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R589;R737.25

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