微管相关蛋白2在胰腺神经内分泌肿瘤组织中的表达及预后意义

发布时间：2018-03-15 11:08

  本文选题：微管相关蛋白　切入点：胰腺神经内分泌肿瘤　出处：《中国肿瘤临床》2017年11期 　论文类型：期刊论文

【摘要】：目的:探索微管相关蛋白2(microtubule-associated protein 2,MAP2)与微管相关蛋白1B(microtubule-associated protein 1B,MAP1B)在预测胰腺神经内分泌肿瘤(pancreatic neuroendocrine tumors,PNETs)患者预后中的意义。方法:收集1999年12月至2016年12月来自于北京协和医院、中山大学附属第一医院、复旦大学上海癌症中心和Cedars-Sinai医学中心(洛杉矶)193例患者的193个原发肿瘤标本。免疫组织化学染色法分别检测193例、120例PNETs组织中MAP2、MAP1B的表达,随后分析蛋白表达与患者临床病理特征及预后的关系。结果:MAP2和MAP1B在PNETs患者中的阳性率分别为45.6%(88/193)和64.2%(77/120)。MAP2表达阳性的患者的总生存好于阴性患者(P=0.012)。另外,MAP2阳性Ⅱ、Ⅲ期患者的总生存也优于阴性者(P=0.017)。然而,MAP1B的表达与肿瘤大小、转移、肿瘤组织学分级、临床分期、总生存、无病生存均无相关性(P0.05)。结论:MAP2为潜在的预测PNETs患者预后的指标。
[Abstract]:Objective: to investigate the prognostic significance of microtubule-associated protein 2map2 and microtubule-associated protein 1Bmap1B in patients with pancreatic neuroendocrine tumors. Methods: from December 1999 to December 2016, the patients with pancreatic neuroendocrine tumors were collected from Peking Union Hospital. In the first affiliated Hospital of Sun Yat-sen University, Shanghai Cancer Center of Fudan University and Cedars-Sinai Medical Center, 193 primary tumor specimens were collected from 193 patients of Los Angeles. Immunohistochemical staining was used to detect the expression of MAP2MAP1B in 120 cases of PNETs. Then the relationship between protein expression and clinicopathological characteristics and prognosis was analyzed. Results the positive rates of MAP1B and MP-2 in PNETs patients were 45.6% 88 / 193 and 64.22a / 120% .MAP2 positive patients' overall survival was better than that of negative patients (P < 0.012). In addition, the positive rate of MAP2 in patients with PNETs was higher than that in patients with negative expression of MAP2, and the total survival rate of patients with positive expression of MAP2 was better than that of patients with negative expression of MAP2. However, there was no correlation between the expression of MAP1B and tumor size, metastasis, tumor histological grade, clinical stage, total survival and disease-free survival in stage 鈪，

本文编号：1615768