新辅助化疗在妇科恶性肿瘤中的作用浅谈

发布时间：2018-03-18 21:04

本文选题：新辅助化疗　切入点：宫颈癌　出处：《河北医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：卵巢癌、宫颈癌、子宫内膜癌以及外阴癌是目前女性常见的四大恶性肿瘤,严重影响了女性患者的生命及生活质量。为提升这些患者的生活质量及生存率,新辅助化疗是目前被妇科肿瘤专家研究的越来越多的一种治疗恶性肿瘤的方法。新辅助化疗是为恶性肿瘤患者达到理想肿瘤细胞减灭术及放疗创造有利条件的一种治疗方法。新辅助化疗目前在卵巢癌中应用的研究相对较多,且增加了晚期卵巢癌患者行满意肿瘤细胞减灭手术的机会;随着目前宫颈癌患者的发病率趋于年轻化,而且某些年轻患者有强烈的生育要求,新辅助化疗在宫颈癌中的应用逐渐燃起妇科肿瘤专家及研究者的兴趣;然而新辅助化疗在子宫内膜癌中应用的研究相对较少,通过国内外文献得出目前也有妇科肿瘤专家将新辅助化疗应用于无法行满意手术治疗的子宫内膜癌患者;为了减少晚期外阴癌患者术后的并发症及增加患者术后的生存质量,目前新辅助化疗在外阴癌的应用也不乏少数。本文基于国内外对于新辅助化疗在妇科恶性肿瘤(卵巢癌、宫颈癌、子宫内膜癌以及外阴癌)的应用现状以及作用进行了总结;本文通过对应用新辅助化疗的患者术后的总生存期、无病生存期以及术后的生活质量等的研究,对新辅助化疗在四种恶性肿瘤中应用的适应症、疗效等方面进行了总结;最终对新辅助化疗在恶性肿瘤中应用的前景进行了展望。
[Abstract]:Ovarian cancer, cervical cancer, endometrial carcinoma and vulvar cancer are the four most common malignant tumors in women at present, which seriously affect the life and quality of life of female patients. In order to improve the quality of life and survival rate of these patients, Neoadjuvant chemotherapy is one of the more and more methods for the treatment of malignant tumor, which has been studied by gynecological oncology experts. Neoadjuvant chemotherapy is a favorable condition for patients with malignant tumor to achieve ideal tumor cell reduction and radiotherapy. Neoadjuvant chemotherapy has been widely used in ovarian cancer. It also increases the chance of satisfactory tumor cell reduction in patients with advanced ovarian cancer. As the incidence of cervical cancer tends to be younger, and some young patients have strong fertility requirements, The application of neoadjuvant chemotherapy in cervical cancer has gradually aroused the interest of gynecologic oncology experts and researchers; however, there has been relatively little research on the application of neoadjuvant chemotherapy in endometrial carcinoma. According to the domestic and foreign literature, some gynecological oncology experts apply neoadjuvant chemotherapy to endometrial cancer patients who can not be treated satisfactorily, in order to reduce postoperative complications and increase the quality of life of patients with advanced vulvar cancer. At present, the application of neoadjuvant chemotherapy in vulvar cancer is also few. This paper summarizes the application and effect of neoadjuvant chemotherapy in gynecological malignant tumors (ovarian cancer, cervical cancer, endometrial carcinoma and vulvar cancer). In this paper, the total survival time, disease-free survival time and quality of life of patients with neoadjuvant chemotherapy were studied, and the indications and curative effects of neoadjuvant chemotherapy in four kinds of malignant tumors were summarized. Finally, the prospect of neoadjuvant chemotherapy in malignant tumors was prospected.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.3

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