直肠癌环氧化酶-2的表达预测新辅助放疗敏感性的临床价值

发布时间：2018-03-19 03:14

本文选题：直肠肿瘤　切入点：环氧化酶-　出处：《实用医学杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:探讨环氧化酶-2(COX-2)在直肠癌中的表达及其与直肠癌新辅助放疗敏感性的关系。方法:2013年1月至2016年1月收治并获得随访的直肠癌术前放射治疗的患者102例,免疫组织化学方法检测标本中的COX-2表达,分析其肿瘤及癌旁组织中COX-2的表达水平与放疗敏感性和患者预后的关系。结果:放疗敏感的患者为71例,放疗抵抗患者31例,放疗的敏感率为69.6%,肿瘤组织的COX-2表达显著高于癌旁组织(P0.05),放疗敏感组阳性和强阳性的比例显著低于放疗抵抗组(P0.05),且放疗抵抗组癌旁组织COX-2表达阳性的比例显著高于放疗敏感组(P0.05),肿瘤COX-2阳性或强阳性(OR:4.21,95%CI:1.26~7.17)、癌旁组织COX-2阳性(OR:8.15,95%CI:1.43~38.21)为新辅助放疗抵抗的风险因素,生存分析显示,肿瘤组织COX-2表达阴性或弱阳性的患者生存期明显延长。结论:直肠癌患者中COX-2的表达与新辅助的放疗敏感性及预后具有显著的相关性,检测活检直肠癌肿瘤和癌旁组织中COX-2表达,有可能筛选对放化疗敏感的患者,使其获得更好的预后。
[Abstract]:Objective: to investigate the expression of cyclooxygenase-2 (COX-2) in rectal cancer and its relationship with neoadjuvant radiotherapy sensitivity. Methods: from January 2013 to January 2016, 102 patients with rectal cancer received preoperative radiotherapy. Immunohistochemical method was used to detect the expression of COX-2, and to analyze the relationship between the expression of COX-2 and the sensitivity of radiotherapy and prognosis in tumor and adjacent tissues. Results: there were 71 patients with radiotherapy sensitivity and 31 patients with radiotherapy resistance. The sensitivity rate of radiotherapy was 69.6%. The expression of COX-2 in tumor tissues was significantly higher than that in adjacent tissues (P0.05A). The positive and strong positive rates in radiosensitive group were significantly lower than those in radiotherapy resistance group (P 0.05), and the positive rate of COX-2 expression in adjacent tissues of radiotherapy resistant group was significantly higher. The risk factors of neoadjuvant radiotherapy resistance were: P0.05, COX-2 positive or strongly positive, OR: 4.21, CI: 1.26, 7.17, and COX-2 positive, OR 8.1595, CI1: 1.4338.21, respectively, in radiosensitive group. Survival analysis showed that the survival time of patients with negative or weakly positive COX-2 expression was significantly prolonged. Conclusion: the expression of COX-2 in patients with rectal cancer is significantly correlated with neoadjuvant radiosensitivity and prognosis. To detect the expression of COX-2 in tumor and adjacent tissues of rectal cancer, it is possible to screen the patients who are sensitive to radiotherapy and chemotherapy, so as to obtain a better prognosis.
【作者单位】：佛山市第一人民医院肿瘤中心胸腹放疗科;
【分类号】：R735.37

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