不同分子亚型乳腺癌MRI特征分析

发布时间：2018-03-19 09:23

本文选题：乳腺肿瘤　切入点：磁共振成像　出处：《中国临床医学影像杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的:探讨不同分子亚型乳腺癌的MRI特征。材料与方法 :回顾性分析139例病人的术前乳腺MRI图像,包括强化方式、肿块样病灶强化后形态、边缘、内部强化特征、时间-信号强度曲线(TIC)类型、伴随征象。同时记录免疫组化指标ER、PR、HER-2的受体表达情况及Ki-67水平,按照乳腺癌分子亚型分类,分成Luminal A型、Luminal B型、HER-2阳性型和三阴性乳腺癌(TNBC)。以χ~2检验比较各分子亚型间MRI表现的差异,采用交叉列联表方法分析二者的相关性。结果:Luminal A型32例(23.0%),Luminal B型76例(54.7%),HER-2阳性型14例(10.1%),TNBC 17例(12.2%)。肿块样强化病变119例,非肿块样病变20例。肿块样强化病变中,病变的边缘与分子亚型呈低度相关(C=0.360,P=0.008),内部强化特征与分子亚型呈中度相关(C=0.442,P=0.001),TIC类型与分子亚型呈低度相关(C=0.318,P=0.019),而病灶的形态及伴随征象与分子亚型无相关性(C=0.065,P=0.791)。结论:不同分子亚型乳腺癌的MRI变现各异,分子亚型与部分MRI征象之间存在一定的相关性,通过术前MRI检查有助于初步判定预后及初步确定治疗方案。
[Abstract]:Objective: to investigate the MRI features of breast cancer with different molecular subtypes. Materials and methods: the preoperative MRI images of 139 patients with breast cancer were retrospectively analyzed, including the enhancement mode, the features of enhancement, margin and internal enhancement of tumor-like lesions. The receptor expression and Ki-67 level of ERP / HER-2 were recorded and classified according to the molecular subtype of breast cancer. Luminal A Luminal B positive and triple negative breast cancer were divided into two groups. The difference of MRI expression among different molecular subtypes was compared by 蠂 ~ 2 test. Results there were 32 cases of luminal B with 23% Luminal A and 76 cases of Luminal B with HER-2 positive type 14 cases with HER-2 positive type and 17 cases with TNBC with 10.1% HER-2. There were 119 cases of tumor-like enhancement and 20 cases of non-tumor-like lesions. There was a low correlation between the edge of the lesion and the molecular subtype, and a moderate correlation between the internal enhancement characteristics and the molecular subtype. The type of TIC was low correlated with the molecular subtype, while the morphology and accompanying sign of the lesion were not correlated with the molecular subtype. Conclusion: there is no correlation between the morphology and concomitant signs of the lesion and the molecular subtype. Conclusion: there is a low correlation between the TIC type and the molecular subtype of the lesion, and there is no correlation between the morphology and concomitant signs of the lesion and the molecular subtype. Conclusion: there is no correlation between the morphology and concomitant signs of the lesion and the molecular subtype. Conclusion:. The MRI of different molecular subtypes of breast cancer is different. There is a certain correlation between molecular subtypes and some MRI signs. MRI examination before operation is helpful to determine the prognosis and the treatment plan.
【作者单位】：吉林省肿瘤医院放射科;
【基金】：吉林省科技厅自然科学基金项目(20140101170JC)
【分类号】：R445.2;R737.9

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