探讨Tim-3在非小细胞肺癌浸润巨噬细胞上的表达及其对预后的影响

发布时间：2018-03-19 12:19

  本文选题：T细胞免疫球蛋白和黏蛋白域分子　切入点：非小细胞肺癌　出处：《中国癌症杂志》2017年07期 　论文类型：期刊论文

【摘要】：背景与目的:T细胞免疫球蛋白和黏蛋白域分子3(T cell immunoglobulin and mucin-domaincontaining molecules 3,Tim-3)在免疫调节中起重要作用,参与多种疾病的发生、发展,且与疾病免疫逃逸和疾病临床预后明显相关。该研究旨在探讨负性共刺激分子Tim-3在非小细胞肺癌(non-small cell lung cancer,NSCLC)浸润巨噬细胞中的表达及临床意义。方法:采用免疫组织化学法检测126例NSCLC患者中Tim-3的表达水平,分析肿瘤组织浸润巨噬细胞Tim-3的表达水平与临床病理特征间的关系,并进一步分析Tim-3的表达水平对NSCLC患者预后的影响。结果:Tim-3主要分布于巨噬细胞的细胞质和细胞膜中;Tim-3在肿瘤浸润巨噬细胞中的表达水平与肿瘤大小、淋巴结转移及TNM分期均显著相关(P=0.002、0.045和0.022);Tim-3在肿瘤浸润巨噬细胞中的表达水平可显著影响NSCLC患者的生存及预后,在Ⅲ期NSCLC患者中,Tim-3的表达越高,患者总生存期(overall survival,OS)越短(Ⅲ期:χ~2=12.910,P=0.000,中位OS分别为80和32个月)。而且,Tim-3的表达水平与Ⅲ期NSCLC患者的无疾病生存期(disease free survival,DFS)也显著相关(χ~2=6.135,P=0.013,中位DFS分别为41和24个月),高表达Tim-3的NSCLC患者DFS短。另外,在Ⅲ期NSCLC患者中,Tim-3在淋巴细胞中的表达水平与OS和PFS呈负相关(χ~2=4.737,P=0.030,中位OS分别为80和47个月;χ~2=5.882,P=0.015,中位DFS分别为41和24个月)。结论:Tim-3在肿瘤免疫中起负性调节作用从而促进免疫逃逸,对患者的生存及预后有不良影响。
[Abstract]:Background & AIM: t cell immunoglobulin and mucin domain molecule 3T cell immunoglobulin and mucin-domaincontaining molecules 3 Tim-3 play an important role in immunomodulation and participate in the occurrence and development of many diseases. The purpose of this study was to investigate the expression and clinical significance of negative costimulatory molecule Tim-3 in infiltrated macrophages of non-small cell lung cancer in non-small cell lung cancer. The expression of Tim-3 in 126 patients with NSCLC was detected by tissue chemistry. To analyze the relationship between the expression level of Tim-3 and clinicopathological features in tumor infiltrating macrophages. The effect of Tim-3 expression level on the prognosis of NSCLC patients was further analyzed. Results the expression of Tim-3-3 was mainly distributed in the cytoplasm of macrophages and in the cell membrane of tumor infiltrating macrophages and the tumor size. Lymph node metastasis and TNM staging were significantly correlated with the expression levels of P0. 002, 0. 045 and 0. 022% Tim-3 in tumor infiltrating macrophages, which significantly affected the survival and prognosis of patients with NSCLC, and the higher the expression of TMT-3 in stage 鈪，

本文编号：1634238