新辅助化疗方案对三阴性乳腺癌患者血清LEP、IGF-1、TNF-α水平的影响研究

发布时间：2018-03-20 08:52

本文选题：三阴性乳腺癌　切入点：新辅助化疗　出处：《中国地方病防治杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的探讨新辅助化疗方案对三阴性乳腺癌的疗效及其对患者血清血清瘦素(LEP)、胰岛素样生长因子-1(IGF-1)以及肿瘤坏死因子α(TNF-α)水平的影响。方法将入住本院的90例TNBC患者按照随机数字表法分为对照组与观察组,各45例。对照组采用常规化疗方案:80 mg/m~2的奈达铂(d1)+1 000 mg/m~2的吉西他滨(d1,d8),静滴;观察组采用新辅助化疗方案:75 mg/m~2的多西他赛(d1)+1 000 mg/m~2卡培他滨(d1~14),每3周为一个化疗周期,化疗周期均为2个周期。比较两组临床控制总有效率及临床收益率、治疗前后血清LEP、IGF-1及TNF-α水平、毒副反应发生情况。结果观察组临床控制总有效率及临床收益率均高于对照组;观察组患者治疗后血清LEP水平均低于治疗前及对照组治疗后,观察组患者治疗后IGF-1及TNF-α水平均高于治疗前及对照组治疗后,以上差异均有统计学意义(P0.05)。两组患者毒副反应(贫血、中性粒细胞减少、血小板减少、恶心呕吐、便秘以及脱发)发生率差异均无统计学意义(P0.05)。结论新辅助化疗方案可通过改善TNBC患者血清LEP、IGF-1、TNF-α的水平而发挥作用,应在临床中进行推广。
[Abstract]:Objective to investigate the effect of neoadjuvant chemotherapy regimen on tri-negative breast cancer and its effect on serum leptin, insulin-like growth factor-1 IGF-1 (IGF-1) and tumor necrosis factor 伪 (TNF- 伪) levels. Methods 90 patients with TNBC were enrolled in our hospital. According to the random digital table method, they were divided into control group and observation group. There were 45 cases in each group. The control group was treated with routine chemotherapy regimen of: 80 mg/m~2 / d1) (1 000 mg/m~2) of gemcitabine d1 + d8 (iv); the control group was treated with neo-adjuvant chemotherapy regimen (1: 75 mg/m~2) of docetaxel d1) 1 000 mg/m~2 capecitabine d1 (14), every 3 weeks as a chemotherapy cycle, and the control group was treated with a new adjuvant chemotherapy regimen (1: 75 mg/m~2). The total effective rate of clinical control and clinical rate of return were compared between the two groups, the levels of serum LEPnIGF-1 and TNF- 伪 before and after treatment, and the occurrence of side effects. Results the total effective rate of clinical control and the clinical rate of return in the observation group were higher than those in the control group. The levels of serum LEP in observation group were lower than those before treatment and after treatment in control group. The levels of IGF-1 and TNF- 伪 in observation group were higher than those before treatment and after treatment in control group. There were significant differences between the two groups (anemia, neutropenia, thrombocytopenia, nausea and vomiting). There was no significant difference in the incidence of constipation and alopecia (P 0.05). Conclusion Neoadjuvant chemotherapy regimen can improve the serum level of LEP- IGF-1 and TNF- 伪 in patients with TNBC, and should be popularized in clinical practice.
【作者单位】：复旦大学附属肿瘤医院闵行分院;
【基金】：闵行区卫生和计划生育委员会科研项目
【分类号】：R737.9

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