外泌体在癌相关成纤维细胞与肿瘤细胞交互作用中的研究进展

发布时间：2018-03-20 13:38

本文选题：外泌体　切入点：癌相关成纤维细胞　出处：《中国肿瘤生物治疗杂志》2017年12期 　论文类型：期刊论文

【摘要】：癌相关成纤维细胞(cancer associated fibroblasts,CAF)在肿瘤微环境中起着重要作用,其不仅能影响正常细胞的恶性转化,还促进肿瘤细胞的增殖、侵袭及远处转移。CAF通过物理吸引作用促进癌细胞转移、促进肿瘤血管生成,影响肿瘤细胞的代谢,从而促进恶性侵袭。外泌体在微环境中能够从供体细胞向受体细胞传递分子和遗传物质,是分子在细胞间转移的载体,在CAF与恶性肿瘤细胞沟通中发挥重要作用。CAF分泌外泌体促进肿瘤的发展,肿瘤细胞源性外泌体能激活CAF。外泌体具有作为靶向药物递送载体的潜在作用,外泌体作为生物特异性标志物也可用于癌症的早期检测、诊断和预后,具有较好的临床应用前景。
[Abstract]:Cancer associated fibroblast cancer associated fibroblast (associated) plays an important role in the microenvironment of tumor. It not only affects the malignant transformation of normal cells, but also promotes the proliferation, invasion and distant metastasis of tumor cells. Caf promotes the metastasis of cancer cells through physical attraction. Promoting tumor angiogenesis, affecting the metabolism of tumor cells, and thus promoting malignant invasion. Exosomes can transfer molecules and genetic material from donor cells to recipient cells in microenvironments, and are carriers of molecular metastasis between cells. Caf secretory exocrine can promote the development of tumor. Tumor cell derived exocrine can activate CAF.The exocrine has the potential role as a target drug delivery vector. As a biomarker, exocrine can also be used for early detection, diagnosis and prognosis of cancer.
【作者单位】：昆明医科大学第三附属医院暨云南省肿瘤医院云南省肿瘤研究所;
【基金】：国家自然科学基金资助项目(No.81460358) 云南省詹启敏院士工作站资助项目(No.2015IC002) 云南省卫计委内设研究机构科技计划资助项目(No.2017NS201);云南省卫计委内设研究机构科技计划资助项目(No.2014NS201);云南省卫计委内设研究机构科技计划资助项目(No.2014NS023) 云南省科技厅昆明医科大学应用基础研究联合专项资助(No.2014FB066) 云南省应用基础研究计划资助(No.2011FZ133)~~
【分类号】：R730.2

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