食管癌放疗穿孔防治研究进展

发布时间：2018-03-21 01:27

本文选题：食管癌　切入点：放射治疗　出处：《中华肿瘤防治杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的食管癌是消化道常见肿瘤,放射治疗是食管癌的有效治疗方式之一,而食管穿孔是食管癌放疗的严重并发症,一旦出现,多数患者短期内死亡。本研究旨在通过总结国内外食管癌放疗穿孔防治的研究进展,提高对食管癌放疗穿孔的认识,以改善其生存及预后。方法应用PubMed、中国知网、万方数据库和维普中文期刊服务平台等检索系统,以"食管癌、食管恶性肿瘤食管穿孔、瘘、放射治疗、放疗、近距离放射疗法、腔内放疗、诊断、预防和治疗"为关键词,检索1996-2016相关文献,共筛选出51篇高度相关文献。结果食管癌放疗穿孔的高危因素有T4期、二程放疗等,应注意密切监测放疗反应,谨防穿孔。出现胸痛、呛咳和发热等症状时可通过食管X射线检查、食管CT等检查尽早明确诊断,据情况予手术或介入治疗。结论食管癌放疗穿孔可防可治,临床工作中应注意密切监测放疗不良反应,重视放疗穿孔的预防,一旦发生穿孔,要尽早诊断、尽早治疗,改善生存质量,延长生存期。
[Abstract]:Objective esophageal cancer is a common tumor of digestive tract, radiotherapy is one of the effective treatment methods of esophageal cancer, and esophageal perforation is a serious complication of radiotherapy for esophageal carcinoma. In order to improve the survival and prognosis of esophageal cancer perforation, the purpose of this study was to improve the survival and prognosis of esophageal cancer perforation by means of summarizing the research progress in the prevention and treatment of radiotherapy perforation of esophageal cancer at home and abroad. Wanfang Database and Weipu Chinese Journal Service platform, etc., with the key words "esophageal cancer, esophageal cancer perforation, fistula, radiotherapy, radiotherapy, brachytherapy, intracavitary radiotherapy, diagnosis, prevention and treatment", Results the high risk factors for radiotherapy perforation of esophageal carcinoma were T4 stage, second stage radiotherapy, etc. We should pay close attention to monitor the radiation response and prevent perforation. The symptoms of choking cough and fever can be diagnosed by X-ray examination of esophagus, CT examination of esophagus, and operation or interventional therapy. Conclusion the perforation of radiotherapy for esophageal carcinoma can be prevented and treated. In clinical work, we should pay close attention to monitoring the adverse effects of radiotherapy and pay attention to the prevention of radiotherapy perforation. Once perforation occurs, it is necessary to diagnose and treat it as early as possible, improve the quality of life and prolong the survival time.
【作者单位】：济南大学·山东省医学科学院生命与科学学院;山东省医学科学院·山东大学附属山东省肿瘤医院放疗科;
【基金】：国家自然科学基金(81372413);国家自然科学基金面上项目(81472810) 山东省科技发展计划(2014GSF118138) 山东省转化医学专题重点项目(ZR2015HZ004)
【分类号】：R735.1

【相似文献】